CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010375
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 60 kDa chaperonin 
Protein Synonyms/Alias
 GroEL protein; Protein Cpn60 
Gene Name
 groL 
Gene Synonyms/Alias
 groEL; mopA; MPN_573; MP269 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
9AKELVFGKNARNKLLacetylation[1]
21KLLAGINKLADAVKVacetylation[1]
42QNVILGRKFSNPLITacetylation[1]
132LIITELDKRSKKINTacetylation[1]
158SGSKEIGKLIAQAMAacetylation[1]
337VIGGKGSKETIQKHLacetylation[1]
342GSKETIQKHLDLLNGacetylation[1]
357RLKQTTEKYDTDLLKacetylation[1]
364KYDTDLLKERIAHLSacetylation[1]
388GATELAQKELKLRIEacetylation[1]
432NDSKLADKYKAETSAacetylation[1]
434SKLADKYKAETSAENacetylation[1]
443ETSAENLKEILVGYEacetylation[1]
473NSGVNPVKVFAELRSacetylation[1]
492VGFDAETKKKVDMIRacetylation[1]
493GFDAETKKKVDMIRSacetylation[1]
537VYDIKENKEGSFQE*acetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity). 
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 543 AA 
Protein Sequence
MAKELVFGKN ARNKLLAGIN KLADAVKVTV GPKGQNVILG RKFSNPLITN DGVTIAKEIE 60
LTDPLENIGA KVISVAAVST NDIAGDGTTT ATILAQEMTN RGVEAVNNGA NPVNVRRGIE 120
DASQLIITEL DKRSKKINTN EEIEQVAAIS SGSKEIGKLI AQAMALVGKN GVITTDDAKT 180
INTTLETTEG IEFKGTYASP YMVSDQEKME VVLDQPKILV SAMKINTIKE ILPLLEGSME 240
NGNPLLIVAP DFAEEVVTTL AVNKLRGTIN VVAVKCNEYG ERQKAALEDL AISTGTLAYN 300
NELGGGFKDV TVNHLGEARR VQVAKEKTTV IGGKGSKETI QKHLDLLNGR LKQTTEKYDT 360
DLLKERIAHL SQGVAVVRVG GATELAQKEL KLRIEDALNS TKAAVEEGII SGGGIALLNV 420
STILNDSKLA DKYKAETSAE NLKEILVGYE IVRKSLEAPV RQIIENSGVN PVKVFAELRS 480
EADGVGFDAE TKKKVDMIRS GIIDPTKVTK TALEKAASVA SSLITTSVAV YDIKENKEGS 540
FQE 543 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0042026; P:protein refolding; IEA:HAMAP. 
Interpro
 IPR018370; Chaperonin_Cpn60_CS.
 IPR001844; Chaprnin_Cpn60.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00296; CHAPERONINS_CPN60 
PRINTS
 PR00298; CHAPERONIN60.