| Tag | Content |
|---|
| CPLM ID | CPLM-021060 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier organic anion transporter family member 1C1 |
Protein Synonyms/Alias | BBB-specific anion transporter type 1; Blood-brain barrier-specific anion transporter 1; Solute carrier family 21 member 14; Thyroxine transporter |
Gene Name | Slco1c1 |
Gene Synonyms/Alias | Bsat1; Oatp1c1; Oatpf; Slc21a14 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 319 | GSSSEKSKFITDDPV | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency (By similarity). May play a signifiant role in regulating T4 flux into and out of the brain. |
Sequence Annotation | DOMAIN 474 529 Kazal-like.
CARBOHYD 453 453 N-linked (GlcNAc...) (Potential).
CARBOHYD 524 524 N-linked (GlcNAc...) (Potential).
CARBOHYD 537 537 N-linked (GlcNAc...) (Potential).
DISULFID 480 506 By similarity.
DISULFID 484 495 By similarity.
DISULFID 486 510 By similarity. |
Keyword | Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 716 AA |
Protein Sequence | MDTSSKENAH LFHKNSAQPA GGPSFKAGYP STEEARPCCG KLKVFLGALS FVYFAKALTE 60
GYLKSTITQI ERRFDIPSSL VGIIDGSFEI GNLLVITFVS YFGAKLHRPK IIGAGCLVMG 120
FGTMLIAVPQ FFMEKYSYEK YERYSPSSNL TPNISPCYLE SSSPSPRSIV GKSQNKINDE 180
CEVDTSSSMW VYVFLGNLLR GLGETPIQPL GIAYLDDFAS EDNAAFYIGC VQTVAIIGPI 240
FGFLLGSLCA KLYVDIGFVN LDHITITPKD PQWVGAWWLG YLIAGFLSLL AAVPFWCLPK 300
TLPRSQSRED SGSSSEKSKF ITDDPVNYQM APREESMKIM EMARDFLPSL KSLFRNPVYI 360
LYLCASTVQF NSLFGMVTYK PKYIEQQYGQ SSSKANFVIG LINIPAVALG IFSGGIVMKK 420
FRLGICEATK LYLGSSVFGY LLFLSLFALG CENSSVAGLT VSYQGTKPVS YHERALFSDC 480
NSRCKCSDSK WEPMCGDNGI TYASACLAGC QSSSRSGKNI IFSNCTCVGF AAPKSGNWSG 540
MMGRCQKDNG CSQMFLYFLV ISVITSYTLS LGGIPGYILL LRCIQPQLKS FALGIYTLAV 600
RVLAGIPAPV YFGVLIDTSC LKWGFKKCGS RGSCRLYDSH AFRHIYLGLT TLLGTVSVFL 660
STAVLLVLKK KYVSKRSSFI TAREKIVMSS SVKKETCAAR DHGLQPKYWP GKETRL 716 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0015125; F:bile acid transmembrane transporter activity; IDA:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |