| Tag | Content |
|---|
| CPLM ID | CPLM-010627 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcription factor ETV6 |
Protein Synonyms/Alias | ETS translocation variant 6; ETS-related protein Tel1; Tel |
Gene Name | Etv6 |
Gene Synonyms/Alias | Tel; Tel1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 11 | TPAQSSIKQERISYT | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. |
Sequence Annotation | DOMAIN 41 125 PNT.
DNA_BIND 335 416 ETS.
MOD_RES 2 2 N-acetylserine (By similarity).
MOD_RES 11 11 N6-acetyllysine (By similarity).
MOD_RES 18 18 Phosphothreonine (By similarity).
MOD_RES 22 22 Phosphoserine.
MOD_RES 215 215 Phosphoserine (By similarity).
MOD_RES 251 251 Phosphoserine (By similarity).
MOD_RES 298 298 N6-acetyllysine (By similarity). |
Keyword | 3D-structure; Acetylation; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 485 AA |
Protein Sequence | MSETPAQSSI KQERISYTPP ESPVASHRSS TPLHVHTVPR ALRMEEDSIH LPTHLRLQPI 60
YWSRDDVAQW LKWAENEFSL RPIESNKFEM NGKALLLLTK EDFRYRSPHS GDVLYELLQH 120
ILKQRKSRML FSPFFPPGDS IHTKPEVLLH QNHDEDNCVQ RTPRTPAESV HHNPPTIELL 180
HRPRSPITTN HRPSPDPEQQ RPQRSPLDNM SRRLSPVEKA QGPRLQQENN HQETYPLSVS 240
PVENNHCLPS SPWQESTRVI QLMPSPIMHP LILNPRHSHS VDFKQSRHSE DGMNREGKPI 300
NLSHREDLAY LNHIMVSMSP PEEHAMPIGR IADCRLLWDY VYQLLSDSRY ENFIRWEDKE 360
SKIFRIVDPN GLARLWGNHK NRTNMTYEKM SRALRHYYKL NIIRKEPGQR LLFRFMKTPD 420
EIMSGRTDRL EHLESQVLDE QTYQEDEPTI ASPVGWPRGN LPTGTAGGVM EAGELGVAVK 480
EETRE 485 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IDA:MGI. GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI. GO:0030154; P:cell differentiation; IDA:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |