UniProt Accession

 AL1A1_RAT; P51647; O09184 

Genbank Protein ID

 L42009; AF001896; AF001898; AF001897; U79118; BC061526 

Genbank Nucleotide ID

 AAA96657.1; AAC53304.1; AAC53306.1; AAC53305.1; AAB63423.1; AAH61526.1 

Protein Name

 Retinal dehydrogenase 1 

Protein Synonyms/Alias

 RALDH 1; RalDH1; ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic 

Gene Name

 Aldh1a1 

Gene Synonyms/Alias

 Aldh 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
22	NLKIQHTKIFINNEW	acetylation	[1]
36	WHDSVSGKKFPVLNP	acetylation	[1]
128	SDLGGSIKALKYCAG	acetylation	[1]
252	TGSTQVGKLIKEAAG	acetylation	[1]
329	KSVERAKKYVLGNPL	acetylation	[1]
348	NQGPQIDKEQHDKIL	acetylation	[1]
353	IDKEQHDKILDLIES	acetylation	[1]
412	VQQIMKFKSIDDVIK	acetylation	[1]
419	KSIDDVIKRANNTTY	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Is capable of converting 9-cis and all-trans retinal to corresponding retinoic acid with high efficiency, 9-cis retinal being 2-fold more active than all-trans retinal. 

Sequence Annotation

 NP_BIND 246 251 NAD (By similarity).
 ACT_SITE 269 269 Proton acceptor (By similarity).
 ACT_SITE 303 303 Nucleophile (By similarity).
 BINDING 456 456 NAD (By similarity).
 MOD_RES 2 2 N-acetylserine (Probable).
 MOD_RES 91 91 N6-acetyllysine (By similarity).
 MOD_RES 128 128 N6-acetyllysine (By similarity).
 MOD_RES 252 252 N6-acetyllysine (By similarity).
 MOD_RES 353 353 N6-acetyllysine (By similarity).
 MOD_RES 367 367 N6-acetyllysine (By similarity).
 MOD_RES 410 410 N6-acetyllysine (By similarity).
 MOD_RES 419 419 N6-acetyllysine (By similarity).
 MOD_RES 435 435 N6-acetyllysine (By similarity).
 MOD_RES 495 495 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 501 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0004028; F:3-chloroallyl aldehyde dehydrogenase activity; TAS:RGD.
 GO:0018479; F:benzaldehyde dehydrogenase (NAD+) activity; IDA:RGD.
 GO:0042802; F:identical protein binding; IDA:RGD.
 GO:0001758; F:retinal dehydrogenase activity; IDA:RGD.
 GO:0042904; P:9-cis-retinoic acid biosynthetic process; IEA:Compara.
 GO:0042905; P:9-cis-retinoic acid metabolic process; IDA:RGD.
 GO:0060206; P:estrous cycle phase; IEP:RGD.
 GO:0001822; P:kidney development; IEP:RGD.
 GO:0001889; P:liver development; IEP:RGD.
 GO:0007494; P:midgut development; IEP:RGD.
 GO:0002072; P:optic cup morphogenesis involved in camera-type eye development; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IDA:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0045471; P:response to ethanol; IDA:RGD.
 GO:0006979; P:response to oxidative stress; IMP:RGD.
 GO:0032526; P:response to retinoic acid; IEP:RGD.
 GO:0002138; P:retinoic acid biosynthetic process; IMP:RGD.
 GO:0042572; P:retinol metabolic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 

Pfam

 PF00171; Aldedh 

SMART

  

PROSITE

 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 

PRINTS