| Tag | Content |
|---|
| CPLM ID | CPLM-016304 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | F-box only protein 11 |
Protein Synonyms/Alias | Vitiligo-associated protein 1; VIT-1 |
Gene Name | FBXO11 |
Gene Synonyms/Alias | FBX11; VIT1; UG063H01 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 197 | ANDPILWKRLYMEVF | ubiquitination | [1] | | 871 | ICVNCIKKCHQGHDV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Substrate recognition component of the a (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53. |
Sequence Annotation | DOMAIN 153 199 F-box.
REPEAT 395 417 PbH1 1.
REPEAT 418 440 PbH1 2.
REPEAT 441 463 PbH1 3.
REPEAT 464 486 PbH1 4.
REPEAT 487 509 PbH1 5.
REPEAT 510 532 PbH1 6.
REPEAT 533 555 PbH1 7.
REPEAT 556 578 PbH1 8.
REPEAT 579 601 PbH1 9.
REPEAT 602 624 PbH1 10.
REPEAT 625 647 PbH1 11.
REPEAT 648 670 PbH1 12.
REPEAT 671 693 PbH1 13.
REPEAT 694 716 PbH1 14.
REPEAT 717 739 PbH1 15.
REPEAT 740 762 PbH1 16.
REPEAT 763 785 PbH1 17.
REPEAT 786 808 PbH1 18.
REPEAT 809 830 PbH1 19.
ZN_FING 833 904 UBR-type. |
Keyword | Alternative splicing; Complete proteome; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 927 AA |
Protein Sequence | MNSVRAANRR PRRVSRPRPV QQQQQQPPQQ PPPQPPQQQP PQQQPPPPPQ QQQQQQPPPP 60
PPPPPPLPQE RNNVGERDDD VPADMVAEES GPGAQNSPYQ LRRKTLLPKR TACPTKNSME 120
GASTSTTENF GHRAKRARVS GKSQDLSAAP AEQYLQEKLP DEVVLKIFSY LLEQDLCRAA 180
CVCKRFSELA NDPILWKRLY MEVFEYTRPM MHPEPGKFYQ INPEEYEHPN PWKESFQQLY 240
KGAHVKPGFA EHFYSNPARY KGRENMLYYD TIEDALGGVQ EAHFDGLIFV HSGIYTDEWI 300
YIESPITMIG AAPGKVADKV IIENTRDSTF VFMEGSEDAY VGYMTIRFNP DDKSAQHHNA 360
HHCLEITVNC SPIIDHCIIR STCTVGSAVC VSGQGACPTI KHCNISDCEN VGLYITDHAQ 420
GIYEDNEISN NALAGIWVKN HGNPIIRRNH IHHGRDVGVF TFDHGMGYFE SCNIHRNRIA 480
GFEVKAYANP TVVRCEIHHG QTGGIYVHEK GRGQFIENKI YANNFAGVWI TSNSDPTIRG 540
NSIFNGNQGG VYIFGDGRGL IEGNDIYGNA LAGIQIRTNS CPIVRHNKIH DGQHGGIYVH 600
EKGQGVIEEN EVYSNTLAGV WVTTGSTPVL RRNRIHSGKQ VGVYFYDNGH GVLEDNDIYN 660
HMYSGVQIRT GSNPKIRRNK IWGGQNGGIL VYNSGLGCIE DNEIFDNAMA GVWIKTDSNP 720
TLRRNKIHDG RDGGICIFNG GRGLLEENDI FRNAQAGVLI STNSHPILRK NRIFDGFAAG 780
IEITNHATAT LEGNQIFNNR FGGLFLASGV NVTMKDNKIM NNQDAIEKAV SRGQCLYKIS 840
SYTSYPMHDF YRCHTCNTTD RNAICVNCIK KCHQGHDVEF IRHDRYVAHL LDILPNYFPP 900
HFSNIWVSFC FRFFCDCGAG TLSNPCTLAG EPTHDTDTLY DSAPPIESNT LQHN 954 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HGNC. GO:0005730; C:nucleolus; IDA:HPA. GO:0000151; C:ubiquitin ligase complex; NAS:UniProtKB. GO:0016274; F:protein-arginine N-methyltransferase activity; IDA:BHF-UCL. GO:0004842; F:ubiquitin-protein ligase activity; NAS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0007605; P:sensory perception of sound; IEA:Compara. GO:0006511; P:ubiquitin-dependent protein catabolic process; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |