UniProt Accession

 IFT43_HUMAN; Q96FT9; B3KPT6; B4DZI9; G3V385; O95418; Q9ULA9 

Genbank Protein ID

 AK056735; AK302944; AF107885; AC008015; BC010436 

Genbank Nucleotide ID

 BAG51798.1; BAG64101.1; AAC79728.1; AAF03245.1; AAH10436.1 

Protein Name

 Intraflagellar transport protein 43 homolog 

Protein Synonyms/Alias

  

Gene Name

 IFT43 

Gene Synonyms/Alias

 C14orf179 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
69	GWAGDSVKASKFRRK	ubiquitination	[1]
76	KASKFRRKASEEIED	ubiquitination	[1]
159	IDLKLLTKVLAPEHE	ubiquitination	[2, 3, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Component of IFT complex A (IFT-A) involved in retrograde ciliary transport along microtubules from the ciliary tip to the base. 

Sequence Annotation

 MOD_RES 78 78 Phosphoserine.  

Keyword

 Alternative splicing; Ciliopathy; Cilium biogenesis/degradation; Complete proteome; Cytoplasm; Cytoskeleton; Ectodermal dysplasia; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 208 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0030991; C:intraflagellar transport particle A; IDA:UniProtKB.
 GO:0060271; P:cilium morphogenesis; IMP:UniProtKB.
 GO:0035721; P:intraflagellar retrograde transport; IMP:UniProtKB. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS