| Tag | Content |
|---|
| CPLM ID | CPLM-015664 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Semaphorin-6D |
Protein Synonyms/Alias | |
Gene Name | Sema6d |
Gene Synonyms/Alias | Kiaa1479 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 736 | QQNIDSPKLYSNLLT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections (By similarity). |
Sequence Annotation | DOMAIN 27 512 Sema.
DOMAIN 514 569 PSI.
CARBOHYD 51 51 N-linked (GlcNAc...) (Potential).
CARBOHYD 283 283 N-linked (GlcNAc...) (Potential).
CARBOHYD 435 435 N-linked (GlcNAc...) (Potential).
CARBOHYD 461 461 N-linked (GlcNAc...) (Potential).
CARBOHYD 631 631 N-linked (GlcNAc...) (Potential).
DISULFID 108 118 By similarity.
DISULFID 136 145 By similarity.
DISULFID 259 370 By similarity.
DISULFID 284 329 By similarity.
DISULFID 477 506 By similarity.
DISULFID 515 533 By similarity.
DISULFID 521 568 By similarity.
DISULFID 525 541 By similarity. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Membrane; Neurogenesis; Reference proteome; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1073 AA |
Protein Sequence | MGFLLLWFCV LFLLVSRLRA VSFPEDDEPL NTVDYHYSRQ YPVFRGRPSG NESQHRLDFQ 60
LMLKIRDTLY IAGRDQVYTV NLNEIPQTEV IPSKKLTWRS RQQDRENCAM KGKHKDECHN 120
FIKVFVPRND EMVFVCGTNA FNPMCRYYRL RTLEYDGEEI SGLARCPFDA RQTNVALFAD 180
GKLYSATVAD FLASDAVIYR SMGDGSALRT IKYDSKWIKE PHFLHAIEYG NYVYFFFREI 240
AVEHNNLGKA VYSRVARICK NDMGGSQRVL EKHWTSFLKA RLNCSVPGDS FFYFDVLQSI 300
TDIIQINGIP TVVGVFTTQL NSIPGSAVCA FSMDDIEKVF KGRFKEQKTP DSVWTAVPED 360
KVPKPRPGCC AKHGLAEAYK TSIDFPDDTL AFIKSHPLMD SAVPPIADEP WFTKTRVRYR 420
LTAIEVDRSA GPYQNYTVIF VGSEAGVVLK VLAKTSPFSL NDSVLLEEIE AYNPAKCSAE 480
SEEDRKVVSL QLDKDHHALY VAFSSCVVRI PLSRCERYGS CKKSCIASRD PYCGWLSQGV 540
CERVTLGMLP GGYEQDTEYG NTAHLGDCHE SLPPSTTPDY KIFGGPTSDM EVSSSSVTTV 600
ASSPEITSKV IDTWRPKLTS SRKFVVQDDP NTSDFTDTIS GIPKGVRWEV QSGESNQMVH 660
MNVLITCVFA AFVLGAFIAG VAVYCYRDMF VRKNRKIHKD AESAQSCTDS SGSFAKLNGL 720
FDSPVKEYQQ NIDSPKLYSN LLTSRKELPP NTDTKSMAVD HRGQPPELAA LPTPESTPVL 780
HQKTLQAMKS HSEKAHSHGA SRKEHPQFFP SSPPPHSPLS HGHIPSAIVL PNATHDYNTS 840
FSNSNAHKAE KKLQSMDHPL TKSSSKREHR RSVDSRNTLN DLLKHLNDPN SNPKAILGEI 900
HMAHQTLMLD PVGPMAEVPP KVPNREASLY SPPSTLPRNS PTKRVDVPTT PGVPMTSLER 960
QRGYHKNSSQ RHSISAVPKN LNSPNGVLLS RQPSMNRGGY MPTPTGAKVD YIQGTPVSVH 1020
LQPSLSRQSS YTSNGTLPRT GLKRTPSLKP DVPPKPSFVP QTTSVRPLNK YTY 1073 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IEA:Compara. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004872; F:receptor activity; IEA:InterPro. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0014912; P:negative regulation of smooth muscle cell migration; IDA:MGI. GO:0014911; P:positive regulation of smooth muscle cell migration; IDA:MGI. GO:0021591; P:ventricular system development; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |