CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016672
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dedicator of cytokinesis protein 10 
Protein Synonyms/Alias
 Zizimin-3 
Gene Name
 Dock10 
Gene Synonyms/Alias
 Kiaa0694; Ziz3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
370DPDIDTLKLQKRDSFubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. 
Sequence Annotation
 DOMAIN 181 290 PH.
 DOMAIN 672 850 DHR-1.
 DOMAIN 1690 2150 DHR-2.
 MOD_RES 376 376 Phosphoserine.
 MOD_RES 834 834 N6-acetyllysine (By similarity).
 MOD_RES 1232 1232 Phosphoserine (By similarity).
 MOD_RES 1292 1292 Phosphoserine.
 MOD_RES 1295 1295 Phosphoserine.
 MOD_RES 1318 1318 Phosphoserine (By similarity).
 MOD_RES 1440 1440 Phosphothreonine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Guanine-nucleotide releasing factor; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2150 AA 
Protein Sequence
MAGERTRRFT RSLLRPGQAA ELRHSAASAA AVAVSSRQQQ RQEKPRLLDP LDYETVIEEL 60
EKTYRDDPLQ DLLFFPSDDF STATVSWDIR TLYSTVPEEA EHRAESLLVK EACKFYSSQW 120
YVVNYKYEQY SGDIRQLPRA EHKPEKLPSH SFEVDHEDAD KDEDTTSHSS SKGGGGAGGT 180
GVFKSGWLYK GNFNSTVNNT VTVRSFKKRY FQLTQLPDNS YIMNFYKDEK ISKEPKGCIF 240
LDSCTGVVQN NRLRKYAFEL KMNDLTYFVL AAETESDMDE WIHTLNRILQ ISPEGPLQGR 300
KSAELAELGL DPLDNCVTCE CTLEETDSSE NSLHPDFAKY LTETEDTVKT TRNMGRLNLF 360
SLDPDIDTLK LQKRDSFENE LMIKPFEEKA AKRIMIICRA LNFNLQGCVT ENEYDPVTNI 420
EPFFVSVALY DLRDNRKISA DFHVDLNHPA VRQMLSGTPP ALENGNIDTG TPRQSEEPHI 480
KGLPEEWLKF PKQAVFSVSD PHSEIVLVAK VEKVLMGNIG SGAEPYIKNP DSNKFAQKIL 540
KSNRQFCSKL GKYRMPFAWA VRSVFKDNQG NVDRDSRFSP LYRQESSKMS SEDLLKLVSD 600
YRRADRISKM QSIPGSLDIA VDNIPLEHPN CVTSSFIPVK PFNVSAQSEP TVEVEEFIYD 660
STKYCRPYRV YKNQIYVYPK HLKYDSQKCF NKARNITVCI EFKNSDDDGA KPMKCIYGKP 720
GGPLFTSSAY TAVLHHSQNP DFSDEVKIEL PTQLHGKHHL LFSFYHITCD INAKANAKKK 780
EALETSVGYA WLPLMKHDQI ASQEYNIPIA TTLPPNYLSI QDPTSAKHGG SDIKWVDGGK 840
PLFKVSTFVV STVNTQDPHV NAFFRQCQKR EKDMSQSPTS SFVRACKNLL NVDKIHSIMS 900
FLPIILNQLF KILVQNEEDE ITATVTRVLA DIVAKCHEEQ LDHSVQSYIK FVFKTKSYKE 960
RTIHEELAKN LSDLLKSNDS TIVKHVLEHS WFFFAIILKS MAQHLIDTNK IQLPRAQRFP 1020
ESYQSELDNL VMGLCDHVIW KCKEAPEETK RANHSVARFL KRCFTFMDRG FVFKMVNNYI 1080
SMFSSGEFKT LCQYKFDFLQ EVCQHEHFIP LCLPIRSANI PDPLTPSESI RELHASDMPE 1140
YSVTNEFCRK HFLIGILLRE VGFALQEDQD IRHLALAVLK NLMAKHSFDD RYREPRKQAQ 1200
IASLYMPLYG MLLDNMPRIY LKDLYPFTVN TSNQGSRDDL STNGGFQTQT SMKHATSVDT 1260
SFSKDVLNSI AAFSSIAIST VNHADSRASL ASLDSNPSTT EKSSEKTDNC EKIPRPLSLI 1320
GSTLRFDKLD QAETRSLLMC FLHIMKTISD ETLIAYWQRA PSPEVSDFFS ILDVCLQNFR 1380
YLGKRNIIRK IAAAFKFVQS TQNNGTLKGS NPSCQTSGLL SQWMHTTSGH EGHKQHRSQT 1440
LPIIRGKNAL SNPKLLQMLD NSMNSNSNEI DIVHHVDTEA NIATEVCLTI LDLLSLFTQV 1500
HQRQLQQSDC QNSLMKRVFD TYMLFFQVNQ SASALKHVFA SLRLFVCKFP SAFFQGPADL 1560
CGSFCYEVLK CCNHRSRLTQ MEASALLYFF MRKNFEFNKQ KSIVRSHLQL IKAVSQLIAD 1620
AGIGGSRFQH SLAITNNFAN GDKQMKNSNF PAEVKDLTKR IRTVLMATAQ MKEHEKDPEM 1680
LVDLQYSLAN SYASTPELRR TWLESMAKIH ARNGDLSEAA MCYIHIAALI AEYLKRKGYW 1740
KMEKICTPPL LPEDTQPCDS NLLLTTPGGG SMFSMGWPAF LSITPNIKEE GAMKEDSGMQ 1800
DTPYNENILV EQLYMCVEFL WKSERYELIA DVNKPIIAVF EKQRDFKKLS DLYYDIHRSY 1860
LKVAEVVNSE KRLFGRYYRV AFYGQAVGFF EEEEGKEYIY KEPKLTGLSE ISQRLLKLYA 1920
DKFGADNVKI IQDSNKVNPK DLDPKYAYIQ VTYVTPFFEE KEIEDRKTDF EMHHNINRFV 1980
FETPFTLSGK KHGGVAEQCK RRTVLTTSHL FPYVKKRIQV ISQSSTELNP IEVAIDEMSR 2040
KVSELNQLCT TEEVDMIRLQ LKLQGSVSVK VNAGPMAYAR AFLEETNAKK YPDNQVKLLK 2100
EIFRQFADAC GQALDVNERL IKEDQLEYQE ELRSHYKDML SELSAIMNEQ 2150 
Gene Ontology
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR027007; DHR-1_domain.
 IPR027357; DHR-2.
 IPR026791; DOCK.
 IPR010703; DOCK_C.
 IPR021816; DOCK_C/D_N.
 IPR026796; DOCK_D.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF06920; Ded_cyto
 PF14429; DOCK-C2
 PF11878; DUF3398
 PF00169; PH 
SMART
 SM00233; PH 
PROSITE
 PS51650; DHR_1
 PS51651; DHR_2
 PS50003; PH_DOMAIN 
PRINTS