CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041911
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase PAK 1 
Protein Synonyms/Alias
 p21 (CDKN1A)-activated kinase 1, isoform CRA_b 
Gene Name
 Pak1 
Gene Synonyms/Alias
 mCG_7049 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
390QVIHRDIKSDNILLGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 544 AA 
Protein Sequence
MSNNGVDIQD KPPAPPMRNT STMIGAGSKD TGTLNHGSKP LPPNPEEKKK KDRFYRSILP 60
GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP EQWARLLQTS NITKSEQKKN 120
PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA EDYNSSNTLN VKTVSETPAV PPVSEDEDDD 180
DDATPPPVIA PRPEHTKSVY TRSVIEPLPV TPTRDVATSP ISPTENNTTP PDALTRNTEK 240
QKKKPKMSDE EILEKLRSIV SVGDPKKKYT RFEKIGQGAS GTVYTAMDVA TGQEVAIKQM 300
NLQQQPKKEL IINEILVMRE NKNPNIVNYL DSYLVGDELW VVMEYLAGGS LTDVVTETCM 360
DEGQIAAVCR ECLQALEFLH SNQVIHRDIK SDNILLGMDG SVKLTDFGFC AQITPEQSKR 420
STMVGTPYWM APEVVTRKAY GPKVDIWSLG IMAIEMIEGE PPYLNENPLR ALYLIATNGT 480
PELQNPEKLS AIFRDFLNRC LEMDVEKRGS AKELLQHQFL KIAKPLSSLT PLIAAAKEAT 540
KNNH 544 
Gene Ontology
 GO:0030424; C:axon; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030425; C:dendrite; IEA:Compara.
 GO:0005925; C:focal adhesion; TAS:MGI.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0030426; C:growth cone; IDA:MGI.
 GO:0014704; C:intercalated disc; IEA:Compara.
 GO:0031965; C:nuclear membrane; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0001726; C:ruffle; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; ISS:MGI.
 GO:0031532; P:actin cytoskeleton reorganization; IEA:Compara.
 GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Compara.
 GO:0032869; P:cellular response to insulin stimulus; IEA:Compara.
 GO:0033554; P:cellular response to stress; IEA:Compara.
 GO:0016358; P:dendrite development; IDA:MGI.
 GO:0060244; P:negative regulation of cell proliferation involved in contact inhibition; IEA:Compara.
 GO:0007528; P:neuromuscular junction development; IGI:MGI.
 GO:0048812; P:neuron projection morphogenesis; IEA:Compara.
 GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IEA:Compara.
 GO:0043507; P:positive regulation of JUN kinase activity; IEA:Compara.
 GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Compara.
 GO:0051496; P:positive regulation of stress fiber assembly; IEA:Compara.
 GO:0046777; P:protein autophosphorylation; IEA:Compara.
 GO:0043113; P:receptor clustering; IGI:MGI.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0042060; P:wound healing; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000095; PAK_box_Rho-bd.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00786; PBD
 PF00069; Pkinase 
SMART
 SM00285; PBD
 SM00220; S_TKc 
PROSITE
 PS50108; CRIB
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS