CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011828
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GTPase-activating protein GYP5 
Protein Synonyms/Alias
  
Gene Name
 GYP5 
Gene Synonyms/Alias
 YPL249C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
152EKVYADTKEVVSSPEubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 GTPase-activating protein which accelerates the GTP hydrolysis rate of YPT1 and SEC4. Involved in ER to Golgi trafficking and polarized exocytosis. 
Sequence Annotation
 DOMAIN 451 630 Rab-GAP TBC.
 MOD_RES 25 25 Phosphoserine.
 MOD_RES 30 30 Phosphoserine.
 MOD_RES 89 89 Phosphothreonine.
 MOD_RES 389 389 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; ER-Golgi transport; Exocytosis; GTPase activation; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 894 AA 
Protein Sequence
MSSDKSIEKN TDTIASEVHE GDNHSNNLGS MEEEIKSTPS DQYEEIAIIP TEPLHSDKEL 60
NDKQQSLGHE APTNVSREEP IGISGDEDTQ ITEQNVNEQR QETREPSSEI DLNEPLDVEK 120
DVTTDVQAPN GLNIEKEYDA VKENEKVYAD TKEVVSSPEN REVTGKNSGG EKSSSSKFLD 180
DESGTTTAAN ANDISISSEV TPERSSENDN NQIHITNEVA AGINLNENKE QKAAIEDGPV 240
TAENLSSETA RKVPPIPTQI INEKGDNSSE NEVSAIPTTS SPPLPPRQNV ATSTSPKLPP 300
RGKQREQPPK TKNAVPPPLE EEMKSEKFRK NFEETKRNSY HHVPLTGSKT AQLESTAEIN 360
LIASRYRKTS HHLNKEGEET RESLQEGQSF LKSTFTSFLE NLSEYNEVEN VNEEDREMFK 420
IDWSFWTQVV NDYATVASNE PENLEAHVTN GIPPQIRGII WQLMANSKSR EMEDIYETLL 480
DTECLHEATI RRDLRRTKFV AEDKMESLYK VIKVYSVYDP DVGYTQGMGF IAAPLLINCE 540
NEAESFGLLV GLMKNYGLRE LFLPGMPGLM LMLYQFDRLL EEHSPSLYNR LIREGISSTM 600
YATQWFLTFF AYKFPLEFVL RIFDIVFVEG IEVLLKFAVN LMLKNEETLV KLRFDELLDF 660
LKDELFNYYL MGNQDDASVV QMGLSNGNSF KGNDDGTFSY NVDLFVHDAM TGVYITPLTL 720
RRYRGEYVEI HEKEQKKEDH YESLRIQNHQ LQREAQKLEH DYSILNKENI SAANELIQNR 780
LNMEMLLDEK NDLINTITDI KSQIEEEIRK QNLPNPDASL PKADLREDLE RTISRNNEVM 840
RENGQLEERI TELQAEIDEL ININKEQVST ASLLERDSKA KGRKGWTGFK KVFK 894 
Gene Ontology
 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0005934; C:cellular bud tip; IDA:SGD.
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005798; C:Golgi-associated vesicle; IDA:SGD.
 GO:0000131; C:incipient cellular bud site; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0005097; F:Rab GTPase activator activity; IGI:SGD.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IGI:SGD.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF00566; RabGAP-TBC 
SMART
 SM00164; TBC 
PROSITE
 PS50086; TBC_RABGAP 
PRINTS