CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028696
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cadherin 17, isoform CRA_a 
Protein Synonyms/Alias
 Cadherin-17 
Gene Name
 Cdh17 
Gene Synonyms/Alias
 mCG_5094 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
406EGKVQLSKQSLKKQDacetylation[1, 2, 3]
410QLSKQSLKKQDSPQYacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Cell adhesion; Complete proteome; Membrane; Reference proteome; Repeat; Transmembrane. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 728 AA 
Protein Sequence
MVSAQLHFLC LLTLYLTCGY GEEGKFSGPL KPMTFSIFEG QEPSQVIFQF KTNPPAVTFE 60
LTGETDGIFK IEKDGLLYHT RALDRETRAV HHLQLAALDS HGAIVDGPVP ITIEVKDIND 120
NRPTFLQSKY EGSVRQNSRP GKPFMYVNAT DLDDPATPNG QLFYQIVIQL PQINDVMYFQ 180
IDSKTGAISL TPEGSQELDP VKNPSYNLVV SVKDMGGQSE NSFSDTTYVD ISIRENIWKA 240
PEPVEIRENS TDPHPIKITQ VQWNDPGAQY SLVNKEKLSP FPFSIDQEGN IYVTQALDRE 300
EKNSHVFFAT AKDENGKPLA YPLEIYVKVI DINDNPPTCL SPVTVFEVQE NEPLGNSIGI 360
FEAHDMDEAN NINSILKYKL VDQTPKVPSD GLFLIGEYEG KVQLSKQSLK KQDSPQYNLS 420
IEVSDVDFKT LCYIQVNVID INDQIPIFET SNYGSKTLSE DTAIGSTILI IQATDADEPF 480
TGSSKILYKI VQGDTEGRLE VVTDPTTNAG YVKIKKPLDF ETQPVSSIVF QAENPEPLVK 540
GIEYNASSFA SFELIVTDVN EVPVFPQRIF QANVSEDAAV GSRVGNVTAR DPEGLTVSYS 600
LKGNMRGWLK IDSVTGEIFS AAPLDRETES VYRVQVVATE VGGSSLSSTA DFHLVLTDVN 660
DNPPRLAKDY TGLFFCHPLS APGSLIFEVT DDDQQSLRRP KFTFALGREG LQSDWEVSKI 720
NGELSNVQ 728 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; TAS:MGI.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005427; F:proton-dependent oligopeptide secondary active transmembrane transporter activity; IDA:MGI.
 GO:0016339; P:calcium-dependent cell-cell adhesion; IDA:MGI.
 GO:0007156; P:homophilic cell adhesion; IDA:MGI. 
Interpro
 IPR002126; Cadherin.
 IPR015919; Cadherin-like.
 IPR020894; Cadherin_CS. 
Pfam
 PF00028; Cadherin 
SMART
 SM00112; CA 
PROSITE
 PS00232; CADHERIN_1
 PS50268; CADHERIN_2 
PRINTS
 PR00205; CADHERIN.