Tag | Content |
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CPLM ID | CPLM-010312 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Hemolysin E, chromosomal |
Protein Synonyms/Alias | Cytotoxin ClyA; Hemolysis-inducing protein; Latent pore-forming 34 kDa hemolysin; Silent hemolysin SheA |
Gene Name | hlyE |
Gene Synonyms/Alias | clyA; hpr; sheA; ycgD; b1182; JW5181 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
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162 | LTNDFSEKSSYFQSQ | acetylation | [1] | 234 | NTVKQANKDIDAAKL | acetylation | [1] |
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Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells. |
Sequence Annotation | DISULFID 87 285 In monomeric form. |
Keyword | 3D-structure; Complete proteome; Cytolysis; Direct protein sequencing; Disulfide bond; Hemolysis; Host cell membrane; Host membrane; Membrane; Periplasm; Reference proteome; Secreted; Toxin; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 303 AA |
Protein Sequence | MTEIVADKTV EVVKNAIETA DGALDLYNKY LDQVIPWQTF DETIKELSRF KQEYSQAASV 60 LVGDIKTLLM DSQDKYFEAT QTVYEWCGVA TQLLAAYILL FDEYNEKKAS AQKDILIKVL 120 DDGITKLNEA QKSLLVSSQS FNNASGKLLA LDSQLTNDFS EKSSYFQSQV DKIRKEAYAG 180 AAAGVVAGPF GLIISYSIAA GVVEGKLIPE LKNKLKSVQN FFTTLSNTVK QANKDIDAAK 240 LKLTTEIAAI GEIKTETETT RFYVDYDDLM LSLLKEAAKK MINTCNEYQK RHGKKTLFEV 300 PEV 303 |
Gene Ontology | GO:0005576; C:extracellular region; IMP:EcoCyc. GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0042597; C:periplasmic space; IMP:EcoCyc. GO:0019835; P:cytolysis; IEA:UniProtKB-KW. GO:0044179; P:hemolysis in other organism; IDA:EcoCyc. GO:0006917; P:induction of apoptosis; IDA:EcoliWiki. GO:0009405; P:pathogenesis; IDA:EcoliWiki. |
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