UniProt Accession

 IGHG4_HUMAN; P01861 

Genbank Protein ID

 K01316; AL928742 

Genbank Nucleotide ID

 AAB59394.1 

Protein Name

 Ig gamma-4 chain C region 

Protein Synonyms/Alias

  

Gene Name

 IGHG4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	DHKPSNTKVDKRVES	glycation	[1]
168	GVEVHNAKTKPREEQ	glycation	[1]

Reference

 [1] Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes.
 Zhang Q, Tang N, Schepmoes AA, Phillips LS, Smith RD, Metz TO.
 J Proteome Res. 2008 May;7(5):2025-32. [PMID: 18396901] 

Functional Description

  

Sequence Annotation

 REGION 1 98 CH1.
 REGION 99 110 Hinge.
 REGION 111 220 CH2.
 REGION 221 327 CH3.
 CARBOHYD 177 177 N-linked (GlcNAc...).
 DISULFID 14 14 Interchain (with a light chain).
 DISULFID 27 83
 DISULFID 106 106 Interchain (with a heavy chain).
 DISULFID 109 109 Interchain (with a heavy chain).
 DISULFID 141 201
 DISULFID 247 305  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin C region; Immunoglobulin domain; Reference proteome; Secreted. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0016020; C:membrane; NAS:UniProtKB.
 GO:0003823; F:antigen binding; IEA:UniProtKB-KW.
 GO:0006958; P:complement activation, classical pathway; TAS:Reactome.
 GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis; TAS:Reactome.
 GO:0045087; P:innate immune response; TAS:Reactome. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set. 

Pfam

 PF07654; C1-set 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS