UniProt Accession

 ALDOC_RAT; P09117; Q54AI4; Q63037 

Genbank Protein ID

 M63656; X06984; AB017483; BC099749; X05277 

Genbank Nucleotide ID

 AAA40717.1; CAA30044.1; BAA75659.1; AAH99749.1; CAA28889.1 

Protein Name

 Fructose-bisphosphate aldolase C 

Protein Synonyms/Alias

 Brain-type aldolase 

Gene Name

 Aldoc 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
13	PALSAEQKKELSDIA	acetylation	[1]
14	ALSAEQKKELSDIAL	acetylation	[1]
28	LRIVAPGKGILAADE	ubiquitination	[2]
42	ESVGSMAKRLSQIGV	acetylation	[1]
101	FVRTIQEKGILVGIK	ubiquitination	[2]
108	KGILVGIKVDKGVVP	acetylation	[1]
108	KGILVGIKVDKGVVP	ubiquitination	[2]
111	LVGIKVDKGVVPLAG	acetylation	[1]
153	AKWRCVLKISDRTPS	acetylation	[1]
230	YLEGTLLKPNMVTPG	acetylation	[1]
330	AATEEFIKRAEMNGL	acetylation	[1]
330	AATEEFIKRAEMNGL	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

  

Sequence Annotation

 ACT_SITE 188 188 Proton acceptor (By similarity).
 ACT_SITE 230 230 Schiff-base intermediate with
 BINDING 56 56 Substrate.
 BINDING 147 147 Substrate.
 MOD_RES 39 39 Phosphoserine (By similarity).
 MOD_RES 111 111 N6-acetyllysine (By similarity).
 MOD_RES 119 119 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Glycolysis; Lyase; Phosphoprotein; Reference proteome; Schiff base. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 363 AA 

Protein Sequence

Gene Ontology

 GO:0030424; C:axon; IDA:RGD.
 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004332; F:fructose-bisphosphate aldolase activity; ISS:UniProtKB.
 GO:0007568; P:aging; IDA:RGD.
 GO:0006915; P:apoptotic process; IMP:RGD.
 GO:0030388; P:fructose 1,6-bisphosphate metabolic process; ISS:UniProtKB.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway.
 GO:0031100; P:organ regeneration; IEP:RGD.
 GO:0051290; P:protein heterotetramerization; IPI:RGD.
 GO:0051289; P:protein homotetramerization; IDA:RGD.
 GO:0001666; P:response to hypoxia; IEP:RGD.
 GO:0014070; P:response to organic cyclic compound; IEP:RGD.
 GO:0010243; P:response to organic nitrogen; IEP:RGD. 

Interpro

 IPR000741; Aldolase_I.
 IPR013785; Aldolase_TIM. 

Pfam

 PF00274; Glycolytic 

SMART

  

PROSITE

 PS00158; ALDOLASE_CLASS_I 

PRINTS