CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031169
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 461 
Protein Synonyms/Alias
 cDNA FLJ54872, highly similar to Zinc finger protein 461 
Gene Name
 ZNF461 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
304QRLHTGEKPYECKQCubiquitination[1, 2]
337GEKPYECKECGKTFRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 540 AA 
Protein Sequence
MAHELVMFRD VAIDVSQEEW ECLNPAQRNL YKEVMLENYS NLVSLGLSVS KPAVISSLEQ 60
GKEPWMVVRE ETGRWCPDLA SRDEPQKLSP KRDIYETELS QWVNMEEFKS HSPERSIFSA 120
IWEGNCHFEQ HQGQEEGYFR QLMINHENMP IFSQHTLLTQ EFYDREKISE CKKCRKIFSY 180
HLFFSHHKRT HSKELSECKE CTEIVNTPCL FKQQTIQNGD KCNECKECWK AFVHCSQLKH 240
LRIHNGEKRY ECNECGKAFN YGSELTLHQR IHTGEKPYEC KECGKAFRQR SQLTQHQRLH 300
TGEKPYECKQ CGKAFIRGFQ LTEHLRLHTG EKPYECKECG KTFRHRSHLT IHQRIHTGEK 360
PYECRECGKA FSYHSSFSHH QKIHSGKKPY ECHECGKAFC DGLQLTLHQR IHTGEKPYEC 420
KECGKTFRQC SHLKRHQRIH TGEKPHECMI CGKAFRLHSH LIQHQRIHTG EKPYECKECG 480
KAFSYHSSFS HHQRIHSGKK PYQCGKAFNH RLQLNLHQTL HTGEKPVRFP LLPPHPSLAS 540 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS