UniProt Accession

 LYPA1_HUMAN; O75608; O43202; Q9UQF9 

Genbank Protein ID

 AF081281; AF291053; AF077198; AF077199; BC008652; BC010397; AF035293 

Genbank Nucleotide ID

 AAC31610.1; AAG10063.1; AAD26993.1; AAD26994.1; AAH08652.1; AAH10397.1; AAB88180.1 

Protein Name

 Acyl-protein thioesterase 1 

Protein Synonyms/Alias

 APT-1; hAPT1; Lysophospholipase 1; Lysophospholipase I; LPL-I; LysoPLA I 

Gene Name

 LYPLA1 

Gene Synonyms/Alias

 APT1; LPL1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
105	ALIDQEVKNGIPSNR	ubiquitination	[1, 2, 3]
224	DVKQFIDKLLPPID*	ubiquitination	[2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity. 

Sequence Annotation

 ACT_SITE 119 119 Charge relay system.
 ACT_SITE 174 174 Charge relay system.
 ACT_SITE 208 208 Charge relay system.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Fatty acid metabolism; Hydrolase; Lipid metabolism; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 230 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0004622; F:lysophospholipase activity; TAS:ProtInc.
 GO:0008474; F:palmitoyl-(protein) hydrolase activity; IMP:UniProtKB.
 GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
 GO:0046209; P:nitric oxide metabolic process; TAS:Reactome.
 GO:0050999; P:regulation of nitric-oxide synthase activity; TAS:Reactome.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR003140; PLipase/COase/thioEstase. 

Pfam

 PF02230; Abhydrolase_2 

SMART

  

PROSITE

  

PRINTS