CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024373
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kelch-like protein 41 
Protein Synonyms/Alias
 Kelch repeat and BTB domain-containing protein 10 
Gene Name
 Klhl41 
Gene Synonyms/Alias
 Kbtbd10 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
471RVFIYNPKKGDWKDLubiquitination[1]
476NPKKGDWKDLAPMKTacetylation[2]
482WKDLAPMKTPRSMFGacetylation[2]
583KEWAGMLKEIRYASGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 
Functional Description
 Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells. 
Sequence Annotation
 DOMAIN 33 100 BTB.
 DOMAIN 135 237 BACK.
 REPEAT 346 398 Kelch 1.
 REPEAT 399 447 Kelch 2.
 REPEAT 448 495 Kelch 3.
 REPEAT 497 542 Kelch 4.
 REPEAT 544 599 Kelch 5.  
Keyword
 Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Kelch repeat; Reference proteome; Repeat; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 606 AA 
Protein Sequence
MDSQRELAEE LRLYQSTLLQ DGLKDLLEEK KFIDCTLKAG DKSFPCHRLI LSACSPYFRE 60
YFLSEIEEEK KKEVALDNVD PAILDLIIKY LYSASIDLND GNVQDIFALS SRFQIPSVFT 120
VCVSYLQKRL APGNCLAILR LGLLLDCPRL AISAREFVSD RFVQICKEED FMQLSPQELI 180
SVISNDSLNV EKEEVVFEAV MKWVRTDKEN RAKNLSEVFD CIRFRLMAEK YFKDHVEKDD 240
IIKSNPEVQK KIKVLKDAFA GKLPEPSKNA EKAGAGEVNG DVGDEDLLPG YLNDIPRHGM 300
FVKDLILLVN DTAAVAYDPM ENECYLTALA EQIPRNHSSL VTQQNQVYVV GGLYVDEENK 360
DQPLQSYFFQ LDNVTSEWVG LPPLPSARCL FGLGEVDDKI YVVAGKDLQT EASLDSVLCY 420
DPVAAKWSEV KNLPIKVYGH NVISHNGMIY CLGGKTDDKK CTNRVFIYNP KKGDWKDLAP 480
MKTPRSMFGV AIHKGKIVIA GGVTEDGLSA SVEAFDLKTN KWEVMTEFPQ ERSSISLVSL 540
AGALYAIGGF AMIQLESKEF APTEVNDIWK YEDDKKEWAG MLKEIRYASG ASCLATRLNL 600
FKLSKL 606 
Gene Ontology
 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005856; C:cytoskeleton; IDA:UniProtKB.
 GO:0031430; C:M band; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.
 GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
 GO:0030239; P:myofibril assembly; IMP:UniProtKB.
 GO:0031275; P:regulation of lateral pseudopodium assembly; IEA:Compara.
 GO:0045661; P:regulation of myoblast differentiation; IMP:UniProtKB.
 GO:2000291; P:regulation of myoblast proliferation; IMP:UniProtKB.
 GO:2001014; P:regulation of skeletal muscle cell differentiation; IMP:MGI.
 GO:0035914; P:skeletal muscle cell differentiation; IDA:UniProtKB. 
Interpro
 IPR011705; BACK.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR017096; Kelch-like_gigaxonin.
 IPR015915; Kelch-typ_b-propeller.
 IPR006652; Kelch_1. 
Pfam
 PF07707; BACK
 PF00651; BTB
 PF01344; Kelch_1 
SMART
 SM00875; BACK
 SM00225; BTB
 SM00612; Kelch 
PROSITE
 PS50097; BTB 
PRINTS