UniProt Accession

 GNA12_HUMAN; Q03113; A4D204; Q2T9L1; Q86UM8; Q8TD71; Q9UDU9 

Genbank Protein ID

 L01694; AF493901; AC006028; AC004933; CH236953; BC111464 

Genbank Nucleotide ID

 AAA35867.1; AAM12615.1; AAP21870.1; AAD05026.1; EAL23961.1; AAI11465.1 

Protein Name

 Guanine nucleotide-binding protein subunit alpha-12 

Protein Synonyms/Alias

 G alpha-12; G-protein subunit alpha-12 

Gene Name

 GNA12 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
70	LGAGESGKSTFLKQM	ubiquitination	[1]
75	SGKSTFLKQMRIIHG	ubiquitination	[1]
198	QLNYFPSKQDILLAR	ubiquitination	[1, 2, 3]
220	EHDFVIKKIPFKMVD	ubiquitination	[1]
376	TILQENLKDIMLQ**	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. 

Sequence Annotation

 NP_BIND 64 71 GTP (By similarity).
 NP_BIND 202 208 GTP (By similarity).
 NP_BIND 227 231 GTP (By similarity).
 NP_BIND 296 299 GTP (By similarity).
 METAL 71 71 Magnesium (By similarity).
 METAL 208 208 Magnesium (By similarity).
 BINDING 353 353 GTP; via amide nitrogen (By similarity).
 MOD_RES 40 40 Phosphoserine (By similarity).
 LIPID 11 11 S-palmitoyl cysteine (By similarity).  

Keyword

 Complete proteome; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Palmitate; Phosphoprotein; Polymorphism; Reference proteome; Transducer. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 381 AA 

Protein Sequence

Gene Ontology

 GO:0031526; C:brush border membrane; IBA:RefGenome.
 GO:0005834; C:heterotrimeric G-protein complex; IBA:RefGenome.
 GO:0031752; F:D5 dopamine receptor binding; IBA:RefGenome.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IBA:RefGenome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IBA:RefGenome.
 GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; IBA:RefGenome.
 GO:0030154; P:cell differentiation; IEA:Compara.
 GO:0042733; P:embryonic digit morphogenesis; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0007243; P:intracellular protein kinase cascade; IEA:Compara.
 GO:0030168; P:platelet activation; TAS:Reactome.
 GO:0008360; P:regulation of cell shape; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0007266; P:Rho protein signal transduction; IBA:RefGenome. 

Interpro

 IPR000469; Gprotein_alpha_12.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00503; G-alpha 

SMART

 SM00275; G_alpha 

PROSITE

  

PRINTS

 PR00318; GPROTEINA.
 PR00440; GPROTEINA12.