UniProt Accession

 HEBP2_HUMAN; Q9Y5Z4; Q96P57 

Genbank Protein ID

 AF117616; AF411610; AY427823; AL031003; BC008205; BC010290; BC093037 

Genbank Nucleotide ID

 AAD32099.1; AAL07394.1; AAR88624.1; CAI20539.1; AAH08205.1; AAH10290.1; AAH93037.1 

Protein Name

 Heme-binding protein 2 

Protein Synonyms/Alias

 Placental protein 23; PP23; Protein SOUL 

Gene Name

 HEBP2 

Gene Synonyms/Alias

 C6orf34; SOUL 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
172	DGKVFDEKVYYTAGY	ubiquitination	[1]
184	AGYNSPVKLLNRNNE	acetylation	[2, 3]
184	AGYNSPVKLLNRNNE	ubiquitination	[1]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions. Does not bind hemin. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 181 181 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Mitochondrion; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 205 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. 

Interpro

 IPR011256; Reg_factor_effector_bac.
 IPR006917; SOUL_haem-bd. 

Pfam

 PF04832; SOUL 

SMART

  

PROSITE

  

PRINTS