UniProt Accession

 BC11B_HUMAN; Q9C0K0; Q9H162 

Genbank Protein ID

 AJ404614; AB043584 

Genbank Nucleotide ID

 CAC17726.1; BAB32731.1 

Protein Name

 B-cell lymphoma/leukemia 11B 

Protein Synonyms/Alias

 BCL-11B; B-cell CLL/lymphoma 11B; COUP-TF-interacting protein 2; Radiation-induced tumor suppressor gene 1 protein; hRit1 

Gene Name

 BCL11B 

Gene Synonyms/Alias

 CTIP2; RIT1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
79	VFIEHKRKQCGGSLG	ubiquitination	[1]
137	PTKGICPKQENIAGK	ubiquitination	[1, 2]
144	KQENIAGKDEPSSYI	ubiquitination	[1, 2]
156	SYICTTCKQPFNSAW	ubiquitination	[1]
356	PQPPAKSKSCEFCGK	ubiquitination	[1]
363	KSCEFCGKTFKFQSN	ubiquitination	[1]
366	EFCGKTFKFQSNLIV	ubiquitination	[1]
385	HTGEKPYKCQLCDHA	ubiquitination	[1]
398	HACSQASKLKRHMKT	ubiquitination	[1]
400	CSQASKLKRHMKTHM	ubiquitination	[1]
514	GAGGGAAKALADEKA	ubiquitination	[1]
520	AKALADEKALVLGKV	ubiquitination	[1]
546	YGELLADKQKRGAFL	ubiquitination	[1]
548	ELLADKQKRGAFLKR	ubiquitination	[1]
554	QKRGAFLKRAAGGGD	ubiquitination	[1]
601	FPGLFPRKPAPLPSP	ubiquitination	[1]
615	PGLNSAAKRIKVEKD	ubiquitination	[1]
652	AASRHFMKDPFLGFT	ubiquitination	[1]
719	GPGRPSSKEGRRSDT	ubiquitination	[1]
732	DTCEYCGKVFKNCSN	ubiquitination	[1]
735	EYCGKVFKNCSNLTV	ubiquitination	[1]
754	HTGERPYKCELCNYA	ubiquitination	[1]
767	YACAQSSKLTRHMKT	ubiquitination	[1]
780	KTHGQIGKEVYRCDI	ubiquitination	[1]
800	SVYSTLEKHMKKWHG	ubiquitination	[1]
803	STLEKHMKKWHGEHL	ubiquitination	[1]
804	TLEKHMKKWHGEHLL	ubiquitination	[1]
816	HLLTNDVKIEQAERS	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). 

Sequence Annotation

 ZN_FING 221 251 C2H2-type 1.
 ZN_FING 427 454 C2H2-type 2.
 ZN_FING 455 482 C2H2-type 3.
 ZN_FING 796 823 C2H2-type 4.
 ZN_FING 824 853 C2H2-type 5.
 ZN_FING 854 884 C2H2-type 6.
 MOD_RES 97 97 Phosphoserine.
 MOD_RES 120 120 Phosphothreonine.
 MOD_RES 256 256 Phosphoserine.
 MOD_RES 260 260 Phosphothreonine.
 MOD_RES 277 277 Phosphoserine.
 MOD_RES 358 358 Phosphoserine.
 MOD_RES 376 376 Phosphothreonine.
 MOD_RES 381 381 Phosphoserine.
 MOD_RES 398 398 Phosphoserine.
 MOD_RES 417 417 Phosphothreonine.
 MOD_RES 483 483 Phosphoserine.
 MOD_RES 488 488 Phosphoserine.
 MOD_RES 496 496 Phosphoserine.
 MOD_RES 497 497 Phosphoserine.
 MOD_RES 678 678 Phosphoserine.
 MOD_RES 765 765 Phosphoserine.
 MOD_RES 851 851 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 894 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Compara.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0046632; P:alpha-beta T cell differentiation; IEA:Compara.
 GO:0003382; P:epithelial cell morphogenesis; IEA:Compara.
 GO:0003334; P:keratinocyte development; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
 GO:0071678; P:olfactory bulb axon guidance; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.
 GO:0043368; P:positive T cell selection; IEA:Compara.
 GO:0031077; P:post-embryonic camera-type eye development; IEA:Compara.
 GO:0010837; P:regulation of keratinocyte proliferation; IEA:Compara.
 GO:0019216; P:regulation of lipid metabolic process; IEA:Compara.
 GO:0045664; P:regulation of neuron differentiation; IEA:Compara.
 GO:0043588; P:skin development; IEA:Compara.
 GO:0021773; P:striatal medium spiny neuron differentiation; IEA:Compara.
 GO:0033077; P:T cell differentiation in thymus; IEA:Compara.
 GO:0033153; P:T cell receptor V(D)J recombination; IEA:Compara.
 GO:0048538; P:thymus development; IEA:Compara. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF00096; zf-C2H2 

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS