UniProt Accession

 ERG26_YEAST; P53199; D6VUD7 

Genbank Protein ID

 Z72523; AY693026; BK006941 

Genbank Nucleotide ID

 CAA96701.1; AAT93045.1; DAA08098.1 

Protein Name

 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating 

Protein Synonyms/Alias

  

Gene Name

 ERG26 

Gene Synonyms/Alias

 YGL001C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
44	DVRDLPEKLSKQFTF	ubiquitination	[1]
273	KADGHIDKHVIVLKR	acetylation	[2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

  

Sequence Annotation

 ACT_SITE 151 151 Proton acceptor (By similarity).
 BINDING 155 155 NAD (By similarity).  

Keyword

 Complete proteome; Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane; NAD; Oxidoreductase; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 349 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.
 GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
 GO:0000252; F:C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity; IDA:SGD.
 GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IEA:EC.
 GO:0006696; P:ergosterol biosynthetic process; IDA:SGD. 

Interpro

 IPR002225; 3Beta_OHSteriod_DH/Estase.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF01073; 3Beta_HSD 

SMART

  

PROSITE

  

PRINTS