| Tag | Content |
|---|
| CPLM ID | CPLM-011810 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ribose-phosphate pyrophosphokinase 5 |
Protein Synonyms/Alias | Phosphoribosyl pyrophosphate synthase 5 |
Gene Name | PRS5 |
Gene Synonyms/Alias | PRPS5; YOL061W; O1213 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 194 | IPMIPGGKLQNTSNS | ubiquitination | [1] | | 290 | SPDAGGAKRATAIAD | ubiquitination | [1] | | 445 | IGQSSIDKLIISNTV | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1- diphosphate synthases (PRS2, PRS3, PRS4 and PRS5). |
Sequence Annotation | METAL 242 242 Magnesium (Potential).
METAL 244 244 Magnesium (Potential).
METAL 253 253 Magnesium (Potential).
METAL 257 257 Magnesium (Potential).
MOD_RES 119 119 Phosphotyrosine.
MOD_RES 120 120 Phosphothreonine.
MOD_RES 123 123 Phosphoserine.
MOD_RES 127 127 Phosphothreonine.
MOD_RES 332 332 Phosphoserine. |
Keyword | ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Metal-binding; Nucleotide biosynthesis; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 496 AA |
Protein Sequence | MSMSNIVVFG GDSHPELVTK ICENLDIHPS KVELGKFSNG ETNIALRESV REKDVYIIQS 60
GCGQVNDTFM QLLILISACK SASASRVTAV MPYLCYSRQP DIPYTAKGAP IISKPKENYT 120
FESHPGTPVS SSLMTQRPGA ESSLKSLDSA IRSTINLENP QPIRTPNSSA TANNNFDIKK 180
TLSFSRIPMI PGGKLQNTSN STDAGELFNA QNAGYKLWVV QAGTLIAHLL SAAGADHVIT 240
MDLHDPQFPG FFDIPVDNLY CKPIAQNYIQ HRIPDYQDAV IVSPDAGGAK RATAIADALE 300
LSFALIHKER RSQLLKGPPD ATLTSGGSLP VSPRPLVTTL VSSQNTTSSG ATGVAALEMK 360
KTTSTSSTSS QSSNSSKFVQ TTMLVGDVRN KVCIIVDDLV DTSYTITRAA KLLKDQGSTK 420
VYALITHGVF SGDALERIGQ SSIDKLIISN TVPQDRTLQY LGKDRVDVID VSCIIGEAIR 480
RIHNGESISM LFEHGW 496 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:SGD. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0016301; F:kinase activity; IEA:UniProtKB-KW. GO:0000287; F:magnesium ion binding; IEA:InterPro. GO:0004749; F:ribose phosphate diphosphokinase activity; IGI:SGD. GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IMP:SGD. GO:0031505; P:fungal-type cell wall organization; IPI:SGD. GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW. GO:0009156; P:ribonucleoside monophosphate biosynthetic process; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |