UniProt Accession

 B0QYD3_HUMAN; B0QYD3 

Genbank Protein ID

 AL022318 

Genbank Nucleotide ID

  

Protein Name

 DNA dC->dU-editing enzyme APOBEC-3B 

Protein Synonyms/Alias

  

Gene Name

 APOBEC3B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
320	YDYDPLYKEALQMLR	ubiquitination	[1, 2, 3]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 490 AA 

Protein Sequence

Gene Ontology

 GO:0016814; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008152; P:metabolic process; IEA:GOC. 

Interpro

 IPR016192; APOBEC/CMP_deaminase_Zn-bd.
 IPR007904; APOBEC_C.
 IPR013158; APOBEC_N.
 IPR016193; Cytidine_deaminase-like. 

Pfam

 PF05240; APOBEC_C
 PF08210; APOBEC_N 

SMART

  

PROSITE

 PS00903; CYT_DCMP_DEAMINASES 

PRINTS