CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029399
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hepatoma-derived growth factor 
Protein Synonyms/Alias
 cDNA FLJ75113 
Gene Name
 HDGF 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MPEAAVKSTANKYQubiquitination[1]
48FGKPNKRKGFSEGLWubiquitination[1, 2, 3, 4, 5]
64IENNPTVKASGYQSSubiquitination[1]
93AAEGDGDKKGNAEGSacetylation[6]
114LVIDEPAKEKNEKGAacetylation[6, 7]
165PLPMEVEKNSTPSEPacetylation[6]
165PLPMEVEKNSTPSEPubiquitination[3]
194DEEEEATKEDAEAPGubiquitination[1, 3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [7] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 208 AA 
Protein Sequence
MPEAAVKSTA NKYQVFFFGT HETAFLGPKD LFPYEESKEK FGKPNKRKGF SEGLWEIENN 60
PTVKASGYQS SQKKSCVEEP EPEPEAAEGD GDKKGNAEGS SDEEGKLVID EPAKEKNEKG 120
ALKRRAGDLL EDSPKRPKEA ENPEGEEKEA ATLEVERPLP MEVEKNSTPS EPGSGRGPPQ 180
EEEEEEDEEE EATKEDAEAP GIRDHESL 208 
Gene Ontology
  
Interpro
 IPR000313; PWWP. 
Pfam
 PF00855; PWWP 
SMART
  
PROSITE
  
PRINTS