UniProt Accession

 KAD8_HUMAN; Q96MA6; A8K821; Q8N9W9 

Genbank Protein ID

 AK057266; AK093446; AK292186; AL160165; AL445645; AL445645; AL160165; CH471090; BC034776; BC050576 

Genbank Nucleotide ID

 BAB71402.1; BAC04168.1; BAF84875.1; CAH70535.1; CAH70535.1; CAH72109.1; CAH72109.1; EAW88016.1; AAH34776.1; AAH50576.1 

Protein Name

 Adenylate kinase 8 

Protein Synonyms/Alias

 AK 8; ATP-AMP transphosphorylase 8 

Gene Name

 AK8 

Gene Synonyms/Alias

 C9orf98 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
111	RRLYLQRKTVPSALL	ubiquitination	[1]
133	LAEEDCIKQGWILDG	ubiquitination	[1]
281	LGPVGSGKSLQAALL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. 

Sequence Annotation

 NP_BIND 67 72 ATP 1 (By similarity).
 NP_BIND 140 143 AMP 1 (By similarity).
 NP_BIND 278 283 ATP 2 (By similarity).
 NP_BIND 325 327 AMP 2 (By similarity).
 NP_BIND 354 357 AMP 2 (By similarity).
 REGION 58 258 Adenylate kinase 1.
 REGION 87 113 NMPbind 1 (By similarity).
 REGION 177 206 LID 1 (By similarity).
 REGION 269 471 Adenylate kinase 2.
 REGION 298 327 NMPbind 2 (By similarity).
 REGION 391 424 LID 2 (By similarity).
 BINDING 147 147 AMP 1 (By similarity).
 BINDING 203 203 AMP 1 (By similarity).
 BINDING 361 361 AMP 2 (By similarity).
 BINDING 392 392 ATP 2 (By similarity).  

Keyword

 Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Polymorphism; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 479 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0004017; F:adenylate kinase activity; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004127; F:cytidylate kinase activity; IDA:UniProtKB.
 GO:0021591; P:ventricular system development; IEA:Compara. 

Interpro

 IPR000850; Adenylate_kin.
 IPR007862; Adenylate_kinase_lid-dom.
 IPR026867; AK7/AK8.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00406; ADK 

SMART

  

PROSITE

 PS00113; ADENYLATE_KINASE 

PRINTS

 PR00094; ADENYLTKNASE.