UniProt Accession

 RFNG_HUMAN; Q9Y644; O00588 

Genbank Protein ID

 AC135056; AF108139; U94353 

Genbank Nucleotide ID

 AAD34321.1; AAC51359.1 

Protein Name

 Beta-1,3-N-acetylglucosaminyltransferase radical fringe 

Protein Synonyms/Alias

 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 

Gene Name

 RFNG 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
140	KFIESGRKWFCHVDD	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis (By similarity). 

Sequence Annotation

 ACT_SITE 237 237 By similarity.
 METAL 148 148 Manganese (By similarity).
 METAL 261 261 Manganese (By similarity).
 BINDING 74 74 Substrate (By similarity).
 BINDING 147 147 Substrate (By similarity).
 CARBOHYD 113 113 N-linked (GlcNAc...) (Potential).
 DISULFID 114 125 By similarity.
 DISULFID 143 207 By similarity.
 DISULFID 311 320 By similarity.  

Keyword

 Complete proteome; Developmental protein; Differentiation; Disulfide bond; Glycoprotein; Glycosyltransferase; Golgi apparatus; Manganese; Membrane; Metal-binding; Neurogenesis; Reference proteome; Signal-anchor; Transferase; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; NAS:UniProtKB.
 GO:0030173; C:integral to Golgi membrane; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0033829; F:O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity; IEA:EC.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
 GO:0009887; P:organ morphogenesis; NAS:UniProtKB.
 GO:0007389; P:pattern specification process; IEA:InterPro.
 GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Compara.
 GO:0032092; P:positive regulation of protein binding; IEA:Compara. 

Interpro

 IPR017374; Fringe.
 IPR003378; Fringe-like. 

Pfam

 PF02434; Fringe 

SMART

  

PROSITE

  

PRINTS