UniProt Accession

 RTR1_YEAST; P40084; D3DM46 

Genbank Protein ID

 U18917; BK006939 

Genbank Nucleotide ID

 AAB64666.1; DAA07800.1 

Protein Name

 RNA polymerase II subunit B1 CTD phosphatase RTR1 

Protein Synonyms/Alias

 RNA polymerase II-associated protein 2 homolog RTR1; Regulator of transcription 1 

Gene Name

 RTR1 

Gene Synonyms/Alias

 YER139C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
165	FEELLREKASEEDIK	ubiquitination	[1]
172	KASEEDIKSLISGLK	ubiquitination	[1]
192	PDSGTTEKDDTELED	ubiquitination	[1, 2]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase that dephosphorylates 'Ser-5' of the CTD and regulates RNA polymerase II during the transition from 'Ser-5' to 'Ser-2' phosphorylation. 

Sequence Annotation

 ZN_FING 50 136 RTR1-type.  

Keyword

 Complete proteome; Cytoplasm; Hydrolase; Metal-binding; Nucleus; Protein phosphatase; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 226 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0008420; F:CTD phosphatase activity; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0070940; P:dephosphorylation of RNA polymerase II C-terminal domain; IDA:SGD.
 GO:0006366; P:transcription from RNA polymerase II promoter; IMP:SGD. 

Interpro

 IPR007308; DUF408. 

Pfam

 PF04181; RPAP2_Rtr1 

SMART

  

PROSITE

 PS51479; ZF_RTR1 

PRINTS