UniProt Accession

 UCK2_MOUSE; Q99PM9 

Genbank Protein ID

 AF236636; BC023789 

Genbank Nucleotide ID

 AAK14052.1; AAH23789.1 

Protein Name

 Uridine-cytidine kinase 2 

Protein Synonyms/Alias

 UCK 2; Cytidine monophosphokinase 2; Uridine monophosphokinase 2 

Gene Name

 Uck2 

Gene Synonyms/Alias

 Umpk 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
78	EQKAKALKGQFNFDH	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine (By similarity). 

Sequence Annotation

 NP_BIND 27 35 ATP (By similarity).
 BINDING 84 84 Substrate (By similarity).
 BINDING 112 112 Substrate (By similarity).
 BINDING 117 117 Substrate (By similarity).
 BINDING 166 166 Substrate (By similarity).
 BINDING 176 176 Substrate (By similarity).
 BINDING 184 184 Substrate (By similarity).
 BINDING 213 213 ATP (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 254 254 Phosphoserine.  

Keyword

 Acetylation; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0004849; F:uridine kinase activity; IEA:EC.
 GO:0071453; P:cellular response to oxygen levels; IEA:Compara.
 GO:0044211; P:CTP salvage; IEA:UniProtKB-UniPathway.
 GO:0007631; P:feeding behavior; IEA:Compara.
 GO:0048678; P:response to axon injury; IEA:Compara.
 GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR006083; PRK/URK.
 IPR000764; Uridine_kinase. 

Pfam

 PF00485; PRK 

SMART

  

PROSITE

  

PRINTS

 PR00988; URIDINKINASE.