UniProt Accession

 D3Z0K8_MOUSE; D3Z0K8 

Genbank Protein ID

 AC133487 

Genbank Nucleotide ID

  

Protein Name

 Thioredoxin reductase 2, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 Txnrd2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
63	KEAAQLGKKVAVADY	acetylation	[1]
79	EPSPRGTKWGLGGTC	acetylation	[2]
79	EPSPRGTKWGLGGTC	succinylation	[2]
153	QLQDRKVKYFNIKAS	acetylation	[1]
158	KVKYFNIKASFVDEH	acetylation	[2]
158	KVKYFNIKASFVDEH	succinylation	[2]
175	RGVDKGGKATLLSAE	acetylation	[2]
175	RGVDKGGKATLLSAE	succinylation	[2]
285	GCVPSHIKKLPTNQL	acetylation	[1]
329	TRTLNLEKAGISTNP	acetylation	[2]
329	TRTLNLEKAGISTNP	succinylation	[2]
329	TRTLNLEKAGISTNP	ubiquitination	[3]
337	AGISTNPKNQKIIVD	acetylation	[2]
337	AGISTNPKNQKIIVD	succinylation	[2]

Reference

 [1] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Redox-active center; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 491 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0004791; F:thioredoxin-disulfide reductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro.
 GO:0007507; P:heart development; IMP:MGI.
 GO:0030097; P:hemopoiesis; IMP:MGI. 

Interpro

 IPR016156; FAD/NAD-linked_Rdtase_dimer.
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR012999; Pyr_OxRdtase_I_AS.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom.
 IPR006338; Thioredoxin/glutathione_Rdtase. 

Pfam

 PF00070; Pyr_redox
 PF07992; Pyr_redox_2
 PF02852; Pyr_redox_dim 

SMART

  

PROSITE

 PS00076; PYRIDINE_REDOX_1 

PRINTS

 PR00368; FADPNR.