CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038333
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Multidrug resistance-associated protein 1 
Protein Synonyms/Alias
  
Gene Name
 Abcc1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
497TYQVAHMKSKDNRIKubiquitination[1]
504KSKDNRIKLMNEILNacetylation[2]
504KSKDNRIKLMNEILNsuccinylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 643 AA 
Protein Sequence
MALRSFCSAD GSDPLWDWNV TWHTSNPDFT KCFQNTVLTW VPCFYLWSCF PLYFFYLSRH 60
DRGYIQMTHL NKTKTALGFF LWIICWADLF YSFWERSQGV LRAPVLLVSP TLLGITMLLA 120
TFLIQLERRK GVQSSGIMLT FWLVALLCAL AILRSKIISA LKKDAHVDVF RDSTFYLYFT 180
LVLVQLVLSC FSDCSPLFSE TVHDRNPCPE SSASFLSRIT FWWITGMMVH GYRQPLESSD 240
LWSLNKEDTS EEVVPVLVNN WKKECDKSRK QPVRIVYAPP KDPSKPKGSS QLDVNEEVEA 300
LIVKSPHKDR EPSLFKVLYK TFGPYFLMSF LYKALHDLMM FAGPKILELI INFVNDREAP 360
DWQGYFYTAL LFVSACLQTL ALHQYFHICF VSGMRIKTAV VGAVYRKALL ITNAARKSST 420
VGEIVNLMSV DAQRFMDLAT YINMIWSAPL QVILALYFLW LSLGPSVLAG VAVMILMVPL 480
NAVMAMKTKT YQVAHMKSKD NRIKLMNEIL NGIKVLKLYA WELAFQDKVM SIRQEELKVL 540
KKSAYLAAVG TFTWVCTPFL VALSTFAVFV TVDERNILDA KKAFVSLALF NILRFPLNIL 600
PMVISSIVQA SVSLKRLRIF LSHEELEPDS IERRSIKSGG RRE 643 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. 
Interpro
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1. 
Pfam
 PF00664; ABC_membrane 
SMART
  
PROSITE
 PS50929; ABC_TM1F 
PRINTS