CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024525
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Zinc finger protein 716 
Protein Synonyms/Alias
  
Gene Name
 ZNF716 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
239KRIHTGEKPYRCEECubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 16 87 KRAB.
 ZN_FING 157 179 C2H2-type 1; degenerate.
 ZN_FING 185 207 C2H2-type 2; degenerate.
 ZN_FING 213 235 C2H2-type 3.
 ZN_FING 241 263 C2H2-type 4.
 ZN_FING 269 290 C2H2-type 5; degenerate.
 ZN_FING 296 318 C2H2-type 6.
 ZN_FING 324 346 C2H2-type 7.
 ZN_FING 352 374 C2H2-type 8.
 ZN_FING 380 402 C2H2-type 9.
 ZN_FING 408 430 C2H2-type 10.
 ZN_FING 436 458 C2H2-type 11.
 ZN_FING 464 486 C2H2-type 12.  
Keyword
 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 495 AA 
Protein Sequence
MAKRPGPPGS REMGLLTFRD IAIEFSLAEW QCLDHAQQNL YRDVMLENYR NLVSLGIAVS 60
KPDLITCLEQ NKEPQNIKRN EMVAKHPVTC SHFTQDLQSE QGIKDSLQKV ILRRYGKCGQ 120
EDLQVKKCCK SVGECEVHKG GYNYVNQCLS ATQNKTFQTH KCVKVFGKFS NSNRHKTRHT 180
GKKHFKCKND GKSFCMLSRL NQHQIIHTRE KSYKCEECGK SFNCSSTLTR HKRIHTGEKP 240
YRCEECGKAF SWSASLTKHK RIHTGEKPYT CEERGKVFSR STLTNYKRIH TGEKPYTCEE 300
CGKAFSRSST LTNHKRIHTG ERPYKCEECG KAFSLSSTLK KHKIVHTGEK LYTCEECGKA 360
FTFSSTLNTH KRIHTGEKPY TCEECGKAFS LPSTFTYHKR THTGEKPYKC EECGKAFNCS 420
STLKKHKIIH TGEKLYKCKE CGKAFTFSST LNTHKRIHTG EKPYKCEECD QTFKWHSSLA 480
NHKNMHTGEK PYKYE 495 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001909; Krueppel-associated_box.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF01352; KRAB 
SMART
 SM00349; KRAB
 SM00355; ZnF_C2H2 
PROSITE
 PS50805; KRAB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS