| Tag | Content |
|---|
| CPLM ID | CPLM-008303 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein male-specific lethal-1 |
Protein Synonyms/Alias | |
Gene Name | msl-1 |
Gene Synonyms/Alias | CG10385 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 816 | CSPHTYSKATARSGK | acetylation | [1] | | 916 | CRDARYMKEQIRLEQ | acetylation | [1] | | 997 | PTSIARSKALAEPVA | acetylation | [1] | | 1009 | PVATLASKKIPTTAA | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | The MSL proteins are essential for elevating transcription of the single X chromosome in the male (X chromosome dosage compensation). Msl-1 is a pioneer protein. Mle, msl-1 and msl-3 are colocalized on the X chromosome. Each of the MSL proteins requires all the other MSLs for wild-type X-chromosome binding. In complex with msl-2, promotes ubiquitination of histone H2B. |
Sequence Annotation | MOTIF 1032 1037 Nuclear localization signal. |
Keyword | Chromosome; Complete proteome; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1039 AA |
Protein Sequence | MDKRFKWPPK KRANYLESPY PHIPSRGRQR NLHGHPNQTQ HLHQHPGKIY ERQQYGNGRG 60
GHGGGNNNYR KLLHSLPAEH GGGAMAPPSS GGTVCAGADM VKLISENNNL RRMVMLNLNL 120
MQEQTDSIAA KDKELDDQSA KMSVVKAQNE ELKQAVAQLE AANQELCKQL RRKNQRRNDN 180
DDDDDDPPLP PAAPQQKLIR CHAETQTVFR EREQGTQTID AQPQFANALP RGINMKESPA 240
LDHHAGAVTN QPASKRSESK GRGEFNGKKV STFILQRMNQ DFEHHIHEQT EVAEEHEMEA 300
HKEQISQEED QLVAEEDHLH MQEVHTEEVV GGDIFHDALE SIEMEVVTEE LVDMEEHGQS 360
VDANGHIEED DDEDDEDDEN SDKDDDSEED DYPWMHSDAD VNARTEEELW QNQNYLLELD 420
PTEEKTCAPS AHSTPNHQQK SSTQAEIRKE GNQNRITEKL LQLKPEPMVD ALEAPILPKW 480
VAFKKKDKEH ESVPESPEVP KQQPHQEDAI VDHNAIKNQL EVPKPDLKPK DQPKDEQRQD 540
GQLDVRVEPQ EDVRKVQKET LKRQPEDAPK HLPKAVAPKV TKTSSRESTL PKANTADIKD 600
APAQKVIANH QSTKTQTDPV KTQRLQVKIR QYEMHPDMRT GSSAPSDIRK QKNVDPVSTP 660
ETKTIKSKSM LVNDKKTTSE TSQSPDQEID VETVRRKLAE HLKKELLSQS HSSQVTLKKI 720
RERVATNLIY PPPSAPVSST TITPAPTPST TPTPGSTPQH AVTSSMDQEI SAAKSKSKAA 780
EQIATPLTPQ SNSSVSSTTS TIRKTLNNCS PHTYSKATAR SGKLQSRFRT ATFPYSTRTW 840
EDQEFHCDNE FFLEEADELL ADNPSLEIPK WRDVPVPPSS DKIDTELLSD ATFERRHQKY 900
VKDEVDRKCR DARYMKEQIR LEQLRMRRNQ DEVLVALDPL RASTFYPLPE DIEAIQFVNE 960
VTVQAFGENV VNMEARDDFG VPWVDAIEAP TSIARSKALA EPVATLASKK IPTTAAEARH 1020
QENHSSYVFP KRRKRQKNR 1039 |
Gene Ontology | GO:0072487; C:MSL complex; IEA:InterPro. GO:0016456; C:X chromosome located dosage compensation complex, transcription activating; NAS:FlyBase. GO:0003682; F:chromatin binding; IDA:FlyBase. GO:0003677; F:DNA binding; IDA:FlyBase. GO:0016457; P:dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome; TAS:FlyBase. GO:0043984; P:histone H4-K16 acetylation; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |