CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036532
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Eukaryotic translation initiation factor 3 subunit B 
Protein Synonyms/Alias
 eIF3b; Eukaryotic translation initiation factor 3 subunit 9 
Gene Name
 eIF3-S9 
Gene Synonyms/Alias
 CG4878; Dmel_CG4878 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
74VEPVRLEKLKLVINKacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome (By similarity). 
Sequence Annotation
 DOMAIN 57 141 RRM (By similarity).
 REPEAT 207 246 WD 1 (By similarity).
 REPEAT 293 331 WD 2 (By similarity).
 REPEAT 334 369 WD 3 (By similarity).
 REPEAT 442 484 WD 4 (By similarity).
 REPEAT 530 575 WD 5 (By similarity).  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome; Repeat; RNA-binding; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 690 AA 
Protein Sequence
MAKKKSEEHS GTDANDSDYQ EEPNFDDPPG FVDNISDEDL LGDMLAQRPS EADGVESVVV 60
VDNIPKVEPV RLEKLKLVIN KLFSNYGEIV NVVYPVDEEG KTKGYAFMEY KQARQAEEAV 120
KKLNNHRLDK NHTFAVNLFT DFQKYENIPE KWEPPTVQTF KVQSDLYNFI NDPDTYDQYC 180
VAAETAPNCV QVGFWQNVLP EPFELETRER FTDTFVKWSP LGTYVVTFHK PGVAIWGGSS 240
FQKIQKFPHP GTQFVEFSPC ENYLVTYGPT PTGQKIIIWD IRTGAEKRSF VADGMSVLSM 300
FRWSHDDKFV ARMGENSIHI YETPSFYLLD LKSIKIPGIR GFSWSPTDNV IAYWVEEQNQ 360
IPARVTLMEI PKKREIRNKN LFHVADCKLH WQKSGDYLCV KVDRYSKLKK DKKDLDVKFL 420
GMFYNFEIFH MREKEIPVDS VEIRELILAF AWEPVGNKFS IIHGETNSSN VSFYEVNKGV 480
KPSLVKRLEK KSCTHLFWSP RGQFIVMANL TMGTFEFVDS TNDYIITASP DHFRASEVEW 540
DPTGRYVVTG VSSWKVKEDT GFNMYTFQGR IIKRTILKNF VQFLWRPRPP TLLSEEKQKE 600
IKKNLKKYYA AFEQKDRLRL TRASKELLEK RSQLRETFME YRNKRIAEWA EQKSRRIMLR 660
GHVDTDNLET DEVDEEIVEF LVKEEVTLLE 690 
Gene Ontology
 GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP.
 GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP.
 GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:HAMAP.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003743; F:translation initiation factor activity; IEA:HAMAP.
 GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP.
 GO:0006446; P:regulation of translational initiation; IEA:HAMAP. 
Interpro
 IPR011400; EIF3B.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR013979; TIF_beta_prop-like.
 IPR015943; WD40/YVTN_repeat-like_dom. 
Pfam
 PF08662; eIF2A
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS