UniProt Accession

 GID4_YEAST; P38263; D6VQA4 

Genbank Protein ID

 U86750; X78993; Z35974; AY693057; BK006936 

Genbank Nucleotide ID

 AAC23706.1; CAA55608.1; CAA85060.1; AAT93076.1; DAA07224.1 

Protein Name

 Vacuolar import and degradation protein 24 

Protein Synonyms/Alias

 Glucose-induced degradation protein 4 

Gene Name

 VID24 

Gene Synonyms/Alias

 GID4; YBR105C; YBR0834 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
13	KVDSVAEKPKAVTSK	ubiquitination	[1]
15	DSVAEKPKAVTSKQS	ubiquitination	[1]
20	KPKAVTSKQSEQAAS	ubiquitination	[1, 2]
252	GTTNAAKKLPPQQLP	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047] 

Functional Description

 Has a role in the negative regulation of gluconeogenesis. Required for both proteasome-dependent and vacuolar catabolite degradation of fructose-1,6-bisphosphatase (FBPase). Probably regulates FBPase targeting from the FBPase- containing vesicles to the vacuole. 

Sequence Annotation

 MOD_RES 27 27 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasmic vesicle; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:SGD.
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0019898; C:extrinsic to membrane; IDA:SGD.
 GO:0034657; C:GID complex; IDA:SGD.
 GO:0045721; P:negative regulation of gluconeogenesis; IMP:SGD.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:SGD.
 GO:0006623; P:protein targeting to vacuole; IMP:SGD.
 GO:0007039; P:vacuolar protein catabolic process; IMP:SGD.
 GO:0051469; P:vesicle fusion with vacuole; IMP:SGD. 

Interpro

 IPR018618; Vacuolar_import/degrad_Vid24. 

Pfam

 PF09783; Vac_ImportDeg 

SMART

  

PROSITE

  

PRINTS