CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010671
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 5-oxoprolinase 
Protein Synonyms/Alias
 5-oxo-L-prolinase; 5-OPase; Pyroglutamase 
Gene Name
 Oplah 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
175DLEALRGKLEGLLSRacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Catalyzes the cleavage of 5-oxo-L-proline to form L- glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. 
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Direct protein sequencing; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1288 AA 
Protein Sequence
MGSPEGRFHF AIDRGGTFTD VFAQCPGGHV RVLKLLSEDP ANYADAPTEG IRRILEQEEG 60
VLLPRGRPLD TSRIASIRMG TTVATNALLE RQGERVALLV TRGFRDLLHI GTQARPDLFD 120
LAVPMPEVLY EEVLEVDERV VLYRGEPGAG SPVKGRTGDL LEIQQPVDLE ALRGKLEGLL 180
SRGIHSLAVV LMHSYTWAQH EQQVGTLARE LGFTHVSLSS EVMPMVRIVP RGHTACADAY 240
LTPTIQRYVQ GFRRGFQGQL KNVQVLFMRS DGGLAPMDAF SGSRAVLSGP AGGVVGYSAT 300
TYHLEGGQPV IGFDMGGTST DVSRYAGEFE HVFEASTAGV TLQAPQLDIN TVAAGGGSRL 360
FFRSGLFVVG PESAGAHPGP ACYRKGGPVT VTDANLVLGR LLPASFPCIF GPGEDQPLSP 420
EASRKALEAV AMEVNSFLTN GPCPASQLSL EEVAMGFVRV ANEAMCRPIR ALTQARGHDP 480
SAHVLACFGG AGGQHACAIA RALGMDTVHI HRHSGLLSAL GLALADVVHE AQEPCSLSYT 540
PETFAQLDQR LSRLEEQCVD ALQVQGFPRS QISTESFLHL RYQGTDCALM VSAHQHPATA 600
CSPRAGDFGA AFVERYMREF GFIIPERPVV VDDVRVRGTG RSGLQLEDTP KIQTGPPHVE 660
KVTQCYFEGG YQETPVYLLG ELGYGHQLQG PCLIIDNNST ILVEPGCQAE VTDTGDIRIS 720
VGAEGPSMAD TRLDPIQLSI FSHRFMSIAE QMGRILQRTA ISTNIKERLD FSCALFGPDG 780
GLVSNAPHIP VHLGAMQETV QFQIQHLGAD LHPGDVLLSN HPSAGGSHLP DLTVITPVFW 840
PGQTRPVFYV ASRGHHADIG GITPGSMPPH STTLQQEGAV FLSFKLVQGG VFQEEAVTEA 900
LRAPGKISGC SGTRNLHDNL SDLRAQVAAN QKGIQLVGEL IGQYGLDVVQ AYMGHIQANA 960
ELAVRDMLRA FGTSRQARGL PLEVSAEDHM DDGSPICLRV QINLSQGSAV FDFTGSGSEV 1020
FGNLNAPRAI TLSALIYCLR CLVGRDIPLN QGCLAPVRVI IPKGSILDPS PEAAVVGGNV 1080
LTSQRVVDVI LGAFGACSAS QGCMNNVTLG NARMGYYETV AGGAGAGPGW HGRSGVHSHM 1140
TNTRITDPEI LESRYPVILR RFELRPGSGG RGRFRGGDGV VRELVFREEA LLSVLTERRA 1200
FQPYGLHGGE PGARGLNLLI RKDGRTVNLG GKTSVTVYPG DVFCLHTPGG GGYGDPEDPA 1260
PPPGSPPLFP AFPERGSVFE YRRAQEAV 1288 
Gene Ontology
 GO:0017168; F:5-oxoprolinase (ATP-hydrolyzing) activity; IEA:EC.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008152; P:metabolic process; IEA:GOC. 
Interpro
 IPR008040; Hydant_A_N.
 IPR002821; Hydantoinase_A.
 IPR003692; Hydantoinase_B. 
Pfam
 PF05378; Hydant_A_N
 PF01968; Hydantoinase_A
 PF02538; Hydantoinase_B 
SMART
  
PROSITE
  
PRINTS