| Tag | Content |
|---|
| CPLM ID | CPLM-000554 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Endophilin-A1 |
Protein Synonyms/Alias | Endophilin-1; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2; SH3p4 |
Gene Name | Sh3gl2 |
Gene Synonyms/Alias | Sh3d2a; Sh3p4 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 7 | *MSVAGLKKQFHKAT | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. |
Sequence Annotation | DOMAIN 18 249 BAR.
DOMAIN 290 349 SH3.
REGION 1 125 Binds and tubulates liposomes.
REGION 1 21 Membrane-binding amphipathic helix.
REGION 60 87 Required for dimerization upon membrane |
Keyword | 3D-structure; Coiled coil; Complete proteome; Cytoplasm; Endocytosis; Lipid-binding; Membrane; Reference proteome; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 352 AA |
Protein Sequence | MSVAGLKKQF HKATQKVSEK VGGAEGTKLD DDFKEMERKV DVTSRAVMEI MTKTIEYLQP 60
NPASRAKLSM INTMSKIRGQ EKGPGYPQAE ALLAEAMLKF GRELGDDCNF GPALGEVGEA 120
MRELSEVKDS LDMEVKQNFI DPLQNLHDKD LREIQHHLKK LEGRRLDFDY KKKRQGKIPD 180
EELRQALEKF DESKEIAESS MFNLLEMDIE QVSQLSALVQ AQLEYHKQAV QILQQVTVRL 240
EERIRQASSQ PRREYQPKPR MSLEFATGDG TQPNGGLSHT GTPKPAGVQM DQPCCRALYD 300
FEPENEGELG FKEGDIITLT NQIDENWYEG MLHGQSGFFP INYVEILVAL PH 352 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0008289; F:lipid binding; IEA:UniProtKB-KW. GO:0002090; P:regulation of receptor internalization; IEA:Compara. GO:0048488; P:synaptic vesicle endocytosis; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |