UniProt Accession

 ABHDA_HUMAN; Q9NUJ1; D3DN63; Q8TCF9 

Genbank Protein ID

 AK002204; CH471052; CH471052; BC014516; AL713726 

Genbank Nucleotide ID

 BAA92133.1; EAW79688.1; EAW79689.1; AAH14516.1; CAD28516.2 

Protein Name

 Mycophenolic acid acyl-glucuronide esterase, mitochondrial 

Protein Synonyms/Alias

 Alpha/beta hydrolase domain-containing protein 10; Abhydrolase domain-containing protein 10 

Gene Name

 ABHD10 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
69	DLPNLAYKKLKGKSP	ubiquitination	[1]
129	SEESTLGKWRKDVLS	ubiquitination	[1, 2]
194	NQLPVELKKEVEMKG	ubiquitination	[1, 2]
200	LKKEVEMKGVWSMPS	ubiquitination	[3, 4]
248	IRLLHGMKDDIVPWH	ubiquitination	[1, 2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Catalyzes the deglucuronidation of mycophenolic acid acyl-glucuronide, a metabolite of the immunosuppressant drug mycophenolate. 

Sequence Annotation

 ACT_SITE 152 152 Charge relay system (By similarity).
 ACT_SITE 249 249 Charge relay system (By similarity).
 ACT_SITE 279 279 Charge relay system (By similarity).  

Keyword

 Complete proteome; Hydrolase; Mitochondrion; Polymorphism; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 306 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:BHF-UCL.
 GO:0005739; C:mitochondrion; IDA:LIFEdb.
 GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IDA:BHF-UCL.
 GO:0019391; P:glucuronoside catabolic process; IDA:BHF-UCL. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS