| Tag | Content |
|---|
| CPLM ID | CPLM-014322 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Testis-specific serine/threonine-protein kinase 1 |
Protein Synonyms/Alias | TSK-1; TSK1; TSSK-1; Testis-specific kinase 1; Serine/threonine-protein kinase 22A |
Gene Name | Tssk1b |
Gene Synonyms/Alias | Stk22a; Tssk1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 307 | PEPGADKKSATKLEP | acetylation | [1] | | 311 | ADKKSATKLEPREEA | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-281' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. |
Sequence Annotation | DOMAIN 12 272 Protein kinase.
NP_BIND 18 26 ATP (By similarity).
ACT_SITE 136 136 Proton acceptor (By similarity).
BINDING 41 41 ATP (By similarity).
MOD_RES 174 174 Phosphothreonine (By similarity). |
Keyword | ATP-binding; Cell projection; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Developmental protein; Differentiation; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Spermatogenesis; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 365 AA |
Protein Sequence | MDDAAVLKRR GYIMGINLGE GSYAKVKSAY SERLKFNVAV KIIDRKKAPS DFLEKFLPRE 60
IEILAMLNHR SIVKTYEIFE TSDGKVYIVM ELGVQGDLLE FIKTRGALQE DDARKKFHQL 120
SSAIKYCHDL DVVHRDLKCE NLLLDKDFNI KLSDFGFSKR CLRDDSGRLI LSKTFCGSAA 180
YAAPEVLQGI PYQPKVYDIW SLGVILYIMV CGSMPYDDSN IKKMLRIQKE HRVNFPRSKH 240
LTGECKDLIY RMLQPDVNRR LHIDEILNHC WVQPKARGLS SGAINKEGES SRATEPSWIP 300
EPGADKKSAT KLEPREEARS EARSESKPQE DTLQVVRQSE NVGLSSELNR DTEEGHPQQP 360
SETHT 365 |
Gene Ontology | GO:0001669; C:acrosomal vesicle; TAS:UniProtKB. GO:0031514; C:motile cilium; IDA:UniProtKB. GO:0005524; F:ATP binding; ISS:UniProtKB. GO:0000287; F:magnesium ion binding; ISS:UniProtKB. GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0007286; P:spermatid development; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |