| Tag | Content |
|---|
| CPLM ID | CPLM-018559 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Coagulation factor XI |
Protein Synonyms/Alias | FXI; Plasma thromboplastin antecedent; PTA; Coagulation factor XIa heavy chain; Coagulation factor XIa light chain |
Gene Name | F11 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 319 | KGQETCQKTCTNNAR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX (By similarity). |
Sequence Annotation | DOMAIN 20 103 Apple 1.
DOMAIN 110 193 Apple 2.
DOMAIN 200 283 Apple 3.
DOMAIN 291 376 Apple 4.
DOMAIN 390 622 Peptidase S1.
REGION 547 550 Heparin-binding (By similarity).
ACT_SITE 430 430 Charge relay system (By similarity).
ACT_SITE 479 479 Charge relay system (By similarity).
ACT_SITE 574 574 Charge relay system (By similarity).
CARBOHYD 90 90 N-linked (GlcNAc...) (Potential).
CARBOHYD 126 126 N-linked (GlcNAc...) (Potential).
CARBOHYD 297 297 N-linked (GlcNAc...) (Potential).
CARBOHYD 449 449 N-linked (GlcNAc...) (Potential).
CARBOHYD 490 490 N-linked (GlcNAc...) (Potential).
DISULFID 20 103 Potential.
DISULFID 46 76 By similarity.
DISULFID 50 56 By similarity.
DISULFID 110 193 By similarity.
DISULFID 136 165 By similarity.
DISULFID 140 146 By similarity.
DISULFID 200 283 By similarity.
DISULFID 226 255 By similarity.
DISULFID 230 236 By similarity.
DISULFID 291 376 By similarity.
DISULFID 317 348 By similarity.
DISULFID 321 327 By similarity.
DISULFID 339 339 Interchain (Potential).
DISULFID 382 499 Interchain (between heavy and light
DISULFID 415 431 By similarity.
DISULFID 513 580 Potential.
DISULFID 544 559 By similarity.
DISULFID 570 598 Potential. |
Keyword | Blood coagulation; Complete proteome; Disulfide bond; Glycoprotein; Hemostasis; Heparin-binding; Hydrolase; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 624 AA |
Protein Sequence | MTSLHQVLYF IFFASVSSEC VTKVFKDISF QGGDLSTVFT PSATYCRLVC THHPRCLLFT 60
FMAESSSDDP TKWFACILKD SVTEILPMVN MTGAISGYSF KQCPQQLSTC SKDVYVNLDM 120
KGMNYNSSVV KNARECQERC TDDAHCQFFT YATGYFPSVD HRKMCLLKYT RTGTPTTITK 180
LNGVVSGFSL KSCGLSNLAC IRDIFPNTVL ADLNIDSVVA PDAFVCRRIC THHPTCLFFT 240
FFSQAWPKES QRHLCLLKTS ESGLPSTRIT KSHALSGFSL QHCRHSVPVF CHPSFYNDTD 300
FLGEELDIVD VKGQETCQKT CTNNARCQFF TYYPSHRLCN ERNRRGRCYL KLSSNGSPTR 360
ILHGRGGISG YSLRLCKMDN VCTTKINPRV VGGAASVHGE WPWQVTLHIS QGHLCGGSII 420
GNQWILTAAH CFSGIETPKK LRVYGGIVNQ SEINEGTAFF RVQEMIIHDQ YTTAESGYDI 480
ALLKLESAMN YTDFQRPICL PSKGDRNAVH TECWVTGWGY TALRGEVQST LQKAKVPLVS 540
NEECQTRYRR HKITNKMICA GYKEGGKDTC KGDSGGPLSC KYNGVWHLVG ITSWGEGCGQ 600
KERPGVYTNV AKYVDWILEK TQTV 624 |
Gene Ontology | GO:0005615; C:extracellular space; IEA:Compara. GO:0008201; F:heparin binding; IEA:UniProtKB-KW. GO:0070009; F:serine-type aminopeptidase activity; IEA:Compara. GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. GO:0007596; P:blood coagulation; IEA:UniProtKB-KW. GO:0031639; P:plasminogen activation; IEA:Compara. GO:0051919; P:positive regulation of fibrinolysis; IEA:Compara. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. GO:0030193; P:regulation of blood coagulation; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |