CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015083
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 214 
Protein Synonyms/Alias
  
Gene Name
 TMEM214 
Gene Synonyms/Alias
 PP446 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
4****MATKTAGVGRWubiquitination[1]
240IATANLGKFLELLRSubiquitination[2, 3]
383SCPPEMKKELLSSLTubiquitination[1]
444QETIQSLKLTNQELLubiquitination[1, 2, 3]
453TNQELLRKGSSNNQDubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 CARBOHYD 269 269 N-linked (GlcNAc...) (Potential).
 CARBOHYD 307 307 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 689 AA 
Protein Sequence
MATKTAGVGR WEVVKKGRRP GVGAGAGGRG GGRNRRALGE ANGVWKYDLT PAIQTTSTLY 60
ERGFENIMKR QNKEQVPPPA VEPKKPGNKK QPKKVATPPN QNQKQGRFRS LEEALKALDV 120
ADLQKELDKS QSVFSGNPSI WLKDLASYLN YKLQAPLSEP TLSQHTHDYP YSLVSRELRG 180
IIRGLLAKAA GSLELFFDHC LFTMLQELDK TPGESLHGYR ICIQAILQDK PKIATANLGK 240
FLELLRSHQS RPAKCLTIMW ALGQAGFANL TEGLKVWLGI MLPVLGIKSL SPFAITYLDR 300
LLLMHPNLTK GFGMIGPKDF FPLLDFAYMP NNSLTPSLQE QLCQLYPRLK VLAFGAKPDS 360
TLHTYFPSFL SRATPSCPPE MKKELLSSLT ECLTVDPLSA SVWRQLYPKH LSQSSLLLEH 420
LLSSWEQIPK KVQKSLQETI QSLKLTNQEL LRKGSSNNQD VVTCDMACKG LLQQVQGPRL 480
PWTRLLLLLL VFAVGFLCHD LRSHSSFQAS LTGRLLRSSG FLPASQQACA KLYSYSLQGY 540
SWLGETLPLW GSHLLTVVRP SLQLAWAHTN ATVSFLSAHC ASHLAWFGDS LTSLSQRLQI 600
QLPDSVNQLL RYLRELPLLF HQNVLLPLWH LLLEALAWAQ EHCHEACRGE VTWDCMKTQL 660
SEAVHWTWLC LQDITVAFLD WALALISQQ 689 
Gene Ontology
 GO:0005881; C:cytoplasmic microtubule; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR019308; DUF2359_TMEM214. 
Pfam
 PF10151; DUF2359 
SMART
  
PROSITE
  
PRINTS