UniProt Accession

 FKBP_YEAST; P20081; D6W147 

Genbank Protein ID

 Z46843; M57967; M60877; M63892; Z71411; AY557997; BK006947 

Genbank Nucleotide ID

 CAA86890.1; AAA03564.1; AAA34607.1; AAA34962.1; CAA96017.1; AAS56323.1; DAA10413.1 

Protein Name

 FK506-binding protein 1 

Protein Synonyms/Alias

 FKBP; Peptidyl-prolyl cis-trans isomerase; PPIase; Rapamycin-binding protein 

Gene Name

 FPR1 

Gene Synonyms/Alias

 FKB1; RBP1; YNL135C; N1213; N1845 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
42	GTLENGQKFDSSVDR	ubiquitination	[1, 2]
64	IGVGQVIKGWDVGIP	ubiquitination	[2]

Reference

 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. 

Sequence Annotation

 DOMAIN 26 114 PPIase FKBP-type.
 MOD_RES 51 51 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Isomerase; Phosphoprotein; Reference proteome; Rotamase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 114 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IBA:RefGenome.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005528; F:FK506 binding; IBA:RefGenome.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IDA:SGD.
 GO:0006325; P:chromatin organization; IGI:SGD.
 GO:0006457; P:protein folding; IMP:SGD.
 GO:1901710; P:regulation of homoserine biosynthetic process; IGI:SGD. 

Interpro

 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom. 

Pfam

 PF00254; FKBP_C 

SMART

  

PROSITE

 PS50059; FKBP_PPIASE 

PRINTS