UniProt Accession

 MURC_HUMAN; Q5BKX8; B1PRL3; B4DT88 

Genbank Protein ID

 EU487253; AK300099; AL354917; BC090888 

Genbank Nucleotide ID

 ACA62935.1; BAG61900.1; AAH90888.1 

Protein Name

 Muscle-related coiled-coil protein 

Protein Synonyms/Alias

 Muscle-restricted coiled-coil protein 

Gene Name

 MURC 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
192	ARLRKSGKEHIDNIK	acetylation	[1]
216	KTRQNLDKKVNRIRT	ubiquitination	[2]
217	TRQNLDKKVNRIRTR	ubiquitination	[2]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway. 

Sequence Annotation

  

Keyword

 Activator; Coiled coil; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Myogenesis; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 364 AA 

Protein Sequence

Gene Ontology

 GO:0030018; C:Z disc; IEA:Compara.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR026752; Cavin_fam. 

Pfam

  

SMART

  

PROSITE

  

PRINTS