CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018961
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hermansky-Pudlak syndrome 3 protein 
Protein Synonyms/Alias
  
Gene Name
 HPS3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19SQQVVPCKLEPDRFCubiquitination[1]
283STGLADEKRKYSHFQubiquitination[1]
285GLADEKRKYSHFQHLubiquitination[1]
511VDYSNTYKTVKTQSCubiquitination[1]
544SQLEPGEKAELLEAFubiquitination[1]
552AELLEAFKESCGHLGubiquitination[1]
578HLTLPYYKMSGLSMAubiquitination[1]
601TVEDGLQKYERGLIFubiquitination[1]
721RLLIQQRKGQIVPTEubiquitination[1]
750ASVLGLQKNNKIGIEubiquitination[1]
753LGLQKNNKIGIEEADubiquitination[1]
902VLCRTRLKEYEQCIDubiquitination[1]
928PYANHELKEENRTLWubiquitination[1]
938NRTLWWKKLLPELCQubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Involved in early stages of melanosome biogenesis and maturation (By similarity). 
Sequence Annotation
 MOTIF 172 176 Clathrin-binding (Potential).  
Keyword
 Albinism; Alternative splicing; Complete proteome; Cytoplasm; Disease mutation; Hermansky-Pudlak syndrome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1004 AA 
Protein Sequence
MVQLYNLHPF GSQQVVPCKL EPDRFCGGGR DALFVAAGCK VEAFAVAGQE LCQPRCAFST 60
LGRVLRLAYS EAGDYLVAIE EKNKATFLRA YVNWRNKRTE NSRVCIRMIG HNVEGPFSKA 120
FRDQMYIIEM PLSEAPLCIS CCPVKGDLLV GCTNKLVLFS LKYQIINEEF SLLDFERSLI 180
IHIDNITPVE VSFCVGYVAV MSDLEVLIVK LESGPKNGER VHHHPHKTNN RIRRTEEGIS 240
NEISQLESDD FVICQKPLEL LGEKSEQSGL SVTLESTGLA DEKRKYSHFQ HLLYRRFAPD 300
ISSYVLSDDI KLHSLQLLPI YQTGSLTSDG KNLSQEKELL SLFCFFSLPH VGYLYMVVKS 360
VELMSVYQYP EKSQQAVLTP QFLHVITSNN LQCFTVRCSA AAAREEDPYM DTTLKACPPV 420
SMDVCALRIQ LFIGLKAICH FKNHIILLTK AEPEAIPERR QSPKRLLSRK DTSVKIKIPP 480
VAEAGWNLYI VNTISPVQLY KEMVDYSNTY KTVKTQSCIH LLSEAHLLVR AALMDASQLE 540
PGEKAELLEA FKESCGHLGD CYSRLDSQHS HLTLPYYKMS GLSMAEVLAR TDWTVEDGLQ 600
KYERGLIFYI NHSLYENLDE ELNEELAAKV VQMFYVAEPK QVPHILCSPS MKNINPLTAM 660
SYLRKLDTSG FSSILVTLTK AAVALKMGDL DMHRNEMKSH SEMKLVCGFI LEPRLLIQQR 720
KGQIVPTELA LHLKETQPGL LVASVLGLQK NNKIGIEEAD SFFKVLCAKD EDTIPQLLVD 780
FWEAQLVACL PDVVLQELFF KLTSQYIWRL SKRQPPDTTP LRTSEDLINA CSHYGLIYPW 840
VHVVISSDSL ADKNYTEDLS KLQSLICGPS FDIASIIPFL EPLSEDTIAG LSVHVLCRTR 900
LKEYEQCIDI LLERCPEAVI PYANHELKEE NRTLWWKKLL PELCQRIKCG GEKYQLYLSS 960
LKETLSIVAV ELELKDFMNV LPEDGTATFF LPYLLYCSRK KPLT 1004 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0006996; P:organelle organization; IEA:Compara.
 GO:0043473; P:pigmentation; IEA:Compara. 
Interpro
 IPR017216; BLOC-2_complex_Hps3_subunit. 
Pfam
  
SMART
  
PROSITE
  
PRINTS