CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016763
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Enhancer of polycomb homolog 1 
Protein Synonyms/Alias
  
Gene Name
 Epc1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
294MAQRQPVKPTYAIPIacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage (By similarity). 
Sequence Annotation
  
Keyword
 Activator; Alternative splicing; Chromatin regulator; Complete proteome; Growth regulation; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 813 AA 
Protein Sequence
MSKLSFRARA LDASKPLPVF RCEDLPDLHE YASINRAVPQ MPTGMEKEEE SEHHLQRAIS 60
AQQVYGEKRD NMVIPVPEAE SNIAYYESIY PGEFRMPKQL IHIQPFSLDA EQPDYDLDSE 120
DEVFVNKLKK KMDICPLQFE EMIDRLEKGS GQQPVSLQEA KLLLKEDDEL IREVYEYWIK 180
KRKTCRGSSL IPLVKQEKRD GSSTNDPYVA FRRRTEKMQT RKNRKNDEAS YEKMLKLRRD 240
LSRAVTILEM IKRREKSKRE LLHLTLEIME KRYNLGDYSG EIMSEVMAQR QPVKPTYAIP 300
IIPITNSSQF KHQDATDSKE FKVNKQDKAD LIRPKRKYEK KPKVLPPSAA APQQQSPAAL 360
PGFSAKDLNQ YDFPSSDEEP LSQVLSGSSE AEEENDPDGP FAFRRKAGCQ YYAPHLDQTG 420
NWPWTSPKDG GLGDVRYRYC LTTLTVPQRC LGFARRRVGR GGRVVLDRAH SDYDSMFHHL 480
DLDMLSSPQP SPVNQFANTS EPNTSDRSSS KDLSQILVDI KSCRWRHFRP RTPSLPDSDS 540
GELSSRKLHR SISRAGAAQP GAHTCSTSTQ NRSSSGSAHC AFTAEQYQQH QQQLALMQQQ 600
QLAQTQQQQQ ANSSSSAAAQ QGFVSKTLDS ASAQFAASAL MTSEQLLGFK VKDDVVLGLG 660
VNGVLPASGV YKGLHLSSTT PTALVHTSPS TAGSTLLQPS NITQTSGSHS SLSHQVTAAS 720
SATTQVLFGN NIRLTVPSSV PTVNSVTPIN ARHIPRTLSA VPPSALKLAA AANCQVSKVP 780
SSSSVDSVPR ENHESEKPAL NNIADNTVAM EVT 813 
Gene Ontology
 GO:0031965; C:nuclear membrane; ISA:MGI.
 GO:0032777; C:Piccolo NuA4 histone acetyltransferase complex; ISS:UniProtKB.
 GO:0004402; F:histone acetyltransferase activity; IEA:Compara.
 GO:0043968; P:histone H2A acetylation; ISS:UniProtKB.
 GO:0043967; P:histone H4 acetylation; ISS:UniProtKB.
 GO:0045814; P:negative regulation of gene expression, epigenetic; ISA:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISA:MGI.
 GO:0051155; P:positive regulation of striated muscle cell differentiation; ISA:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISA:MGI.
 GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR024943; Enhancer_polycomb.
 IPR019542; Enhancer_polycomb-like_N.
 IPR009607; Enhancer_polycomb_C. 
Pfam
 PF06752; E_Pc_C
 PF10513; EPL1 
SMART
  
PROSITE
  
PRINTS