| Tag | Content |
|---|
| CPLM ID | CPLM-023395 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cullin-associated NEDD8-dissociated protein 1 |
Protein Synonyms/Alias | Cullin-associated and neddylation-dissociated protein 1 |
Gene Name | Cand1 |
Gene Synonyms/Alias | CG5366 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1204 | SALSQIPKANKNQQL | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (Probable). |
Sequence Annotation | REPEAT 44 82 HEAT 1.
REPEAT 127 165 HEAT 2.
REPEAT 168 206 HEAT 3.
REPEAT 365 403 HEAT 4.
REPEAT 425 463 HEAT 5.
REPEAT 510 548 HEAT 6.
REPEAT 604 642 HEAT 7.
REPEAT 644 682 HEAT 8.
REPEAT 861 900 HEAT 9.
REPEAT 976 1014 HEAT 10.
REPEAT 1054 1093 HEAT 11. |
Keyword | Complete proteome; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1248 AA |
Protein Sequence | MASHQYHQIA NLLEKMTSTD KDFRFMATND LMTELQKDSI ILDDESEKKV VRMVLKLLED 60
KNGEVQNLAV KCLGPLVNKV KEIQVETIVD SLCANMMSNT EQLRDISSIG LKTVIAELPQ 120
SSNSLAPNVC QRITGKLSTA IEKEDVSVKL ESLDILADLL SRFGEFLVPF HSTILKALMP 180
QLASSRQAVR KRTIVALSFL LIQANSNAYN GVIDHLLDGL ENPPNPAAIR TYIQCLASIC 240
RQAGHRLCNH IDRSMLLLSQ YSQRDDDELR EFCLQACEAF VMRCPDAINP HIPMILELCL 300
NYITYDPNYN YETDDGDTGN AMDTEDDEYV DSEEYSDDDD MSWKVRRAAA KCLEVLISTR 360
QELVEDFYRS LSPALIARFK EREENVKSDI FHAYVALLKN TRLTDDVAND HDSMDQVSGP 420
TSLLIEQLPL IVKAIQPLMR EKSMKTRQDC FLLLRELLNS LPGALGPYLD SIVPGISYSL 480
NDKSSTSNMK IESLGFLYSL LQGHPPHVFH PHIPLLVPLV VTSVFDPFYK IATEALLVLQ 540
QLVKVIRPLE PNAAKSDFDA PSFVGQVYSC TLQKLKVTDV DQEVKERAIA CMGQIIANMG 600
DMLQNELAVC LPIFMERLKN EVTRLSSVKA LTLIAASSLR IDLTPILHDV LPALGTFLRK 660
NHRALKLHSL DLINKIVINY SSNFEANLLQ TAIVEIPPLI SDSDLHVAQY SLTLLSTVAR 720
RQPQALVGIH EQFLRSVLIL VRSPLLQGSA LNCTLELFQA LVQTQLSGLD YHSLVSKLMA 780
PVLGGNGDVK SRATAGAPSE VVQLHKQAYH SSAKCIAALT QQCPQVATPL ATKLITDLQK 840
RNDTEIIFCL LTIGEIGRHF DLSSIQVLPQ TIIECFGATS EDVKAAASHA LGAVSVGSLQ 900
TYLPLILHEI EVQPKRQYLL LHSLKEVISS LSVSPSGLAQ LLPSVPSIWD QLFKHCECSE 960
EGSRNVVAEC LGKLVLVNPD ELLPQLQQAL RSESATMRTV VVSSVKFTIS DQPQPIDVLL 1020
KQNIGEFLFA LRDPEPQVRR VALVAFNSAV HNKPSLVRDL LPTLLPWLYS ETKVKSELIR 1080
EVEMGPFKHT VDDGLDIRKA AFECMYTLLE QGLDRVDVMQ FLDHVQAGLC DHYDIKMLTY 1140
LMTARLAILC PDKVLLRLDQ FIQQLRDTCT HKVKANSVKQ EYEKQDELKR SALRAVSALS 1200
QIPKANKNQQ LVDFLKSIKE TPELNKIFEY IQKDSITGSS DIIVMDQS 1248 |
Gene Ontology | GO:2000435; P:negative regulation of protein neddylation; IMP:FlyBase. GO:0031647; P:regulation of protein stability; IMP:FlyBase. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |