CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019576
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pannexin-2 
Protein Synonyms/Alias
  
Gene Name
 PANX2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
456IMRVENSKAEKPKPAacetylation[1]
459VENSKAEKPKPARRKacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Structural component of the gap junctions and the hemichannels (By similarity). 
Sequence Annotation
 CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Complete proteome; Gap junction; Glycoprotein; Ion channel; Ion transport; Membrane; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 677 AA 
Protein Sequence
MHHLLEQSAD MATALLAGEK LRELILPGAQ DDKAGALAAL LLQLKLELPF DRVVTIGTVL 60
VPILLVTLVF TKNFAEEPIY CYTPHNFTRD QALYARGYCW TELRDALPGV DASLWPSLFE 120
HKFLPYALLA FAAIMYVPAL GWEFLASTRL TSELNFLLQE IDNCYHRAAE GRAPKIEKQI 180
QSKGPGITER EKREIIENAE KEKSPEQNLF EKYLERRGRS NFLAKLYLAR HVLILLLSAV 240
PISYLCTYYA TQKQNEFTCA LGASPDGAAG AGPAVRVSCK LPSVQLQRII AGVDIVLLCV 300
MNLIILVNLI HLFIFRKSNF IFDKLHKVGI KTRRQWRRSQ FCDINILAMF CNENRDHIKS 360
LNRLDFITNE SDLMYDNVVR QLLAALAQSN HDATPTVRDS GVQTVDPSAN PAEPDGAAEP 420
PVVKRPRKKM KWIPTSNPLP QPFKEPLAIM RVENSKAEKP KPARRKTATD TLIAPLLDRS 480
AHHYKGGGGD PGPGPAPAPA PPPAPDKKHA RHFSLDVHPY ILGTKKAKAE AVPAALPASR 540
SQEGGFLSQA EDCGLGLAPA PIKDAPLPEK EIPYPTEPAR AGLPSGGPFH VRSPPAAPAV 600
APLTPASLGK AEPLTILSRN ATHPLLHINT LYEAREEEDG GPRLPQDVGD LIAIPAPQQI 660
LIATFDEPRT VVSTVEF 677 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0055077; F:gap junction hemi-channel activity; ISS:UniProtKB.
 GO:0006811; P:ion transport; IEA:UniProtKB-KW.
 GO:0034214; P:protein hexamerization; ISS:UniProtKB.
 GO:0002931; P:response to ischemia; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 
Interpro
 IPR000990; Innexin. 
Pfam
 PF00876; Innexin 
SMART
  
PROSITE
 PS51013; PANNEXIN 
PRINTS