CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012570
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SCL-interrupting locus protein 
Protein Synonyms/Alias
 TAL-1-interrupting locus protein 
Gene Name
 STIL 
Gene Synonyms/Alias
 SIL 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
54LSYYRNPKLVVTEKTubiquitination[1]
60PKLVVTEKTIRLAYRubiquitination[1]
127GDFLIPCKVHTQELCubiquitination[1]
151DDFSSALKALQCHICubiquitination[1]
334RFQLLTSKETLHLFKubiquitination[1]
341KETLHLFKNVEPPDKubiquitination[1]
348KNVEPPDKNPIRCELubiquitination[1]
496PNQLNQDKPALLRHCubiquitination[1]
523PHTRNSIKPSSHNGPubiquitination[1]
755SLMPCSPKTTAVEDTubiquitination[1]
955HLLNSSSKETEQPSTubiquitination[1]
963ETEQPSTKAVIISHEubiquitination[1]
992HHSRLVDKDCVLNATubiquitination[1]
1001CVLNATLKQLRSLGVubiquitination[1]
1009QLRSLGVKIDSPTKVubiquitination[1]
1122NMSFATKKYMKRYGLubiquitination[1]
1207TNEVLQTKAKQQLTEubiquitination[1]
1209EVLQTKAKQQLTEKPubiquitination[1]
1215AKQQLTEKPAFLVKNubiquitination[1]
1224AFLVKNLKPSPAVNLubiquitination[1]
1235AVNLRTGKAEFTQHPubiquitination[1]
1244EFTQHPEKENEGDITubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. 
Sequence Annotation
 REGION 584 779 PIN1-binding (By similarity).
 MOD_RES 753 753 Phosphoserine.
 MOD_RES 1135 1135 Phosphoserine.  
Keyword
 Alternative splicing; Chromosomal rearrangement; Complete proteome; Cytoplasm; Developmental protein; Phosphoprotein; Polymorphism; Primary microcephaly; Proto-oncogene; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1287 AA 
Protein Sequence
MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 60
TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 120
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCGKLLS LRVHITSRES 180
LDSVEFDLHW AAVTLANNFK CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE 240
TRKLLLLLES DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI 300
IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP IRCELSAESQ 360
NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE DFSPRPIPSP HPVSQKISKI 420
QPSVPELSLV LDGNFIESNP LPTPLEMVNN ENPPLINHLE HLKPLQPQLY DEKHSPEVEA 480
GEPSLRGIPN QLNQDKPALL RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT 540
VSAGNVQNEE YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST 600
NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA LYCNAFCSSS 660
SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC TVCMHTPKTE SDNGMMGLSP 720
DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM PCSPKTTAVE DTVQAGRQME LVSVEAQSSP 780
GLHMRKGVSI AVSTGASLFW NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG 840
SASSLKAVDI PSFEESNIAV EEEFNQPLSV SNSSSLVVRK EPDVPVFFPS GQLAESVSMC 900
LQTGPTGGAS NNSETSEEPK IEHVMQPLLH QPSDNQKIYQ DLLGQVNHLL NSSSKETEQP 960
STKAVIISHE CTRTQNVYHT KKKTHHSRLV DKDCVLNATL KQLRSLGVKI DSPTKVKKNA 1020
HNVDHASVLA CISPEAVISG LNCMSFANVG MSGLSPNGVD LSMEANAIAL KYLNENQLSQ 1080
LSVTRSNQNN CDPFSLLHIN TDRSTVGLSL ISPNNMSFAT KKYMKRYGLL QSSDNSEDEE 1140
EPPDNADSKS EYLLNQNLRS IPEQLGGQKE PSKNDHEIIN CSNCESVGTN ADTPVLRNIT 1200
NEVLQTKAKQ QLTEKPAFLV KNLKPSPAVN LRTGKAEFTQ HPEKENEGDI TIFPESLQPS 1260
ETLKQMNSMN SVGTFLDVKR LRQLPKLF 1288 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0000578; P:embryonic axis specification; ISS:BHF-UCL.
 GO:0033504; P:floor plate development; ISS:BHF-UCL.
 GO:0030900; P:forebrain development; ISS:BHF-UCL.
 GO:0001947; P:heart looping; ISS:BHF-UCL.
 GO:0001701; P:in utero embryonic development; ISS:BHF-UCL.
 GO:0035264; P:multicellular organism growth; ISS:BHF-UCL.
 GO:0043066; P:negative regulation of apoptotic process; ISS:BHF-UCL.
 GO:0001843; P:neural tube closure; ISS:BHF-UCL.
 GO:0030903; P:notochord development; ISS:BHF-UCL.
 GO:0007224; P:smoothened signaling pathway; ISS:BHF-UCL. 
Interpro
 IPR026123; Sil. 
Pfam
  
SMART
  
PROSITE
  
PRINTS