CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012118
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 V-type proton ATPase 116 kDa subunit a isoform 3 
Protein Synonyms/Alias
 V-ATPase 116 kDa isoform a3; Osteoclastic proton pump 116 kDa subunit; OC-116 kDa; OC116; T-cell immune regulator 1; T-cell immune response cDNA7 protein; TIRC7; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3 
Gene Name
 TCIRG1 
Gene Synonyms/Alias
 ATP6N1C; ATP6V0A3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
459ADRQEENKAGLLDLPubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation. 
Sequence Annotation
  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Hydrogen ion transport; Ion transport; Membrane; Osteopetrosis; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 830 AA 
Protein Sequence
MTFLISYWGE QIGQKIRKIT DCFHCHVFPF LQQEEARLGA LQQLQQQSQE LQEVLGETER 60
FLSQVLGRVL QLLPPGQVQV HKMKAVYLAL NQCSVSTTHK CLIAEAWCSV RDLPALQEAL 120
RDSSMEEGVS AVAHRIPCRD MPPTLIRTNR FTASFQGIVD AYGVGRYQEV NPAPYTIITF 180
PFLFAVMFGD VGHGLLMFLF ALAMVLAENR PAVKAAQNEI WQTFFRGRYL LLLMGLFSIY 240
TGFIYNECFS RATSIFPSGW SVAAMANQSG WSDAFLAQHT MLTLDPNVTG VFLGPYPFGI 300
DPIWSLAANH LSFLNSFKMK MSVILGVVHM AFGVVLGVFN HVHFGQRHRL LLETLPELTF 360
LLGLFGYLVF LVIYKWLCVW AARAASAPSI LIHFINMFLF SHSPSNRLLY PRQEVVQATL 420
VVLALAMVPI LLLGTPLHLL HRHRRRLRRR PADRQEENKA GLLDLPDASV NGWSSDEEKA 480
GGLDDEEEAE LVPSEVLMHQ AIHTIEFCLG CVSNTASYLR LWALSLAHAQ LSEVLWAMVM 540
RIGLGLGREV GVAAVVLVPI FAAFAVMTVA ILLVMEGLSA FLHALRLHWV EFQNKFYSGT 600
GYKLSPFTFA ATDD 614 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0010008; C:endosome membrane; TAS:Reactome.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
 GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
 GO:0005215; F:transporter activity; TAS:ProtInc.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0006968; P:cellular defense response; TAS:ProtInc.
 GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
 GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
 GO:0051701; P:interaction with host; TAS:Reactome.
 GO:0090382; P:phagosome maturation; TAS:Reactome.
 GO:0008284; P:positive regulation of cell proliferation; TAS:ProtInc.
 GO:0015992; P:proton transport; TAS:ProtInc.
 GO:0033572; P:transferrin transport; TAS:Reactome.
 GO:0055085; P:transmembrane transport; TAS:Reactome. 
Interpro
 IPR002490; V-ATPase_116kDa_su.
 IPR026028; V-type_ATPase_116kDa_su_euka. 
Pfam
 PF01496; V_ATPase_I 
SMART
  
PROSITE
  
PRINTS