CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036866
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nicastrin 
Protein Synonyms/Alias
  
Gene Name
 NCSTN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
91RMVYDMEKGKFPVQLubiquitination[1]
93VYDMEKGKFPVQLENubiquitination[1, 2, 3, 4]
145DLLATLEKSGAGVPAubiquitination[1, 2, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 451 AA 
Protein Sequence
MLKPINTTGT LKPDDRVVVA ATRLDSRSFF WNVAPGAESA VASFVTQLAA AEALQKAPDV 60
TTLPRNVMFV FFQGETFDYI GSSRMVYDME KGKFPVQLEN VDSFVELGQV ALRTSLELWM 120
HTDPVSQKNE SVRNQVEDLL ATLEKSGAGV PAVILRRPNQ SQPLPPSSLQ RFLRARNISG 180
VVLADHSGAF HNKYYQSIYD TAENINVSYP EWLSPEEDLN FVTDTAKALA DVATVLGRAL 240
YELAGGTNFS DTVQADPQTV TRLLYGFLIK ANNSWFQSIL RQDLRSYLGD GPLQHYIAVS 300
SPTNTTYVVQ YALANLTGTV VNLTREQCQD PSKVPSENKD LYEYSWVQGP LHSNETDRLP 360
RCVRSTARLA RALSPAFELS QWSSTEYSTW TESRWKDIRA RIFLIASKEL ELITLTVGFG 420
ILIFSLIVTY CINAKADVLF IAPREPGAVS Y 451 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005765; C:lysosomal membrane; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0004175; F:endopeptidase activity; IEA:Compara.
 GO:0050435; P:beta-amyloid metabolic process; IEA:Compara.
 GO:0050673; P:epithelial cell proliferation; IEA:Compara.
 GO:0002262; P:myeloid cell homeostasis; IEA:Compara.
 GO:0016485; P:protein processing; IEA:InterPro.
 GO:0042098; P:T cell proliferation; IEA:Compara. 
Interpro
 IPR008710; Nicastrin. 
Pfam
 PF05450; Nicastrin 
SMART
  
PROSITE
  
PRINTS