CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043651
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ATP-binding cassette sub-family B member 6, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 ABCB6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
312LLNFETVKYYNAESYubiquitination[1, 2, 3]
330RYREAIIKYQGLEWKubiquitination[2, 3, 4, 5]
591AIARTILKAPGIILLubiquitination[1]
619AIQASLAKVCANRTTubiquitination[6, 7]
684EETSEDTKPQTMER*ubiquitination[2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A data set of human endogenous protein ubiquitination sites.
 Shi Y, Chan DW, Jung SY, Malovannaya A, Wang Y, Qin J.
 Mol Cell Proteomics. 2011 May;10(5):M110.002089. [PMID: 20972266]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 690 AA 
Protein Sequence
XLLASVLESL AGACGLWLLV VERSQARQRL AMGIWIKFRH SPGLLLLWTV AFAAENLALV 60
SWNSPQWWWA RADLGQQVRS AAQQSTWRDF GRKLRLLSGY LWPRGSPALQ LVVLICLGLM 120
GLERALNVLV PIFYRNIVNL LTEKAPWNSL AWTVTSYVFL KFLQGGGTGS TGFVSNLRTF 180
LWIRVQQFTS RRVELLIFSH LHELSLRWHL GRRTGEVLRI ADRGTSSVTG LLSYLVFNVI 240
PTLADIIIGI IYFSMFFNAW FGLIVFLCMS LYLTLTIVVT EWRTKFRRAM NTQENATRAR 300
AVDSLLNFET VKYYNAESYE VERYREAIIK YQGLEWKSSA SLVLLNQTQN LVIGLGLLAG 360
SLLCAYFVTE QKLQVGDYVL FGTYIIQLYM PLNWFGTYYR MIQTNFIDME NMFDLLKEET 420
EVKDLPGAGP LRFQKGRIEF ENVHFSYADG RETLQDVSFT VMPGQTLALV GPSGAGKSTI 480
LRLLFRFYDI SSGCIRIDGQ DISQVTQASL RSHIGVVPQD TVLFNDTIAD NIRYGRVTAG 540
NDEVEAAAQA AGIHDAIMAF PEGYRTQVGE RGLKLSGGEK QRVAIARTIL KAPGIILLDE 600
ATSALDTSNE RAIQASLAKV CANRTTIVVA HRLSTVVNAD QILVIKDGCI VERGRHEALL 660
SRGGVYADMW QLQQGQEETS EDTKPQTMER 690 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS